Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive–compulsive disorder
Abstract Background Neuroimaging studies have revealed the role of the right dorsolateral prefrontal cortex (DLPFC) in the neurobiological mechanism of obsessive–compulsive disorder (OCD). However, only a few studies have examined the functional connectivity (FC) pattern of the right DLPFC at rest i...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3333 |
| _version_ | 1797263412396294144 |
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| author | Zhaoxi Zhong Yangpan Ou Yunhui Chen Ping Li Han Shi Dan Lv Cuicui Jia Tinghuizi Shang Lei Sun Ru Yang Xiaoping Wang Wenbin Guo Luxian Lv |
| author_facet | Zhaoxi Zhong Yangpan Ou Yunhui Chen Ping Li Han Shi Dan Lv Cuicui Jia Tinghuizi Shang Lei Sun Ru Yang Xiaoping Wang Wenbin Guo Luxian Lv |
| author_sort | Zhaoxi Zhong |
| collection | DOAJ |
| description | Abstract Background Neuroimaging studies have revealed the role of the right dorsolateral prefrontal cortex (DLPFC) in the neurobiological mechanism of obsessive–compulsive disorder (OCD). However, only a few studies have examined the functional connectivity (FC) pattern of the right DLPFC at rest in OCD. Objective The aim of this research is to examine the FC patterns of the right DLPFC at rest in OCD. Methods Twenty‐eight medication‐free patients with OCD and 20 healthy controls underwent resting‐state functional magnetic resonance imaging. Seed‐based FC and support vector machine (SVM) were used to analyze the imaging data. Results The patients with OCD showed reduced FC values in the right middle temporal gyrus (MTG), right superior temporal gyrus, right ventral anterior cingulate cortex (vACC), and left Crus II. No brain regions showed a remarkable difference in FC values in patients with OCD after 8 weeks of medication treatment. The reduced right DLPFC–right MTG and right DLPFC–right vACC connectivities were correlated with the clinical symptoms of OCD. SVM results showed that reduced right DLPFC–right MTG connectivity at rest could predict the therapeutic response to OCD medication. Conclusions The findings highlight the important role of the right DLPFC in the pathophysiological mechanism of OCD. |
| first_indexed | 2024-03-07T23:34:44Z |
| format | Article |
| id | doaj.art-a551574aecb24dad9a690be14e513e40 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-04-25T00:12:36Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-a551574aecb24dad9a690be14e513e402024-03-13T10:15:39ZengWileyBrain and Behavior2162-32792024-01-01141n/an/a10.1002/brb3.3333Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive–compulsive disorderZhaoxi Zhong0Yangpan Ou1Yunhui Chen2Ping Li3Han Shi4Dan Lv5Cuicui Jia6Tinghuizi Shang7Lei Sun8Ru Yang9Xiaoping Wang10Wenbin Guo11Luxian Lv12Henan Key Laboratory of Biological Psychiatry The Second Affiliated Hospital of Xinxiang Medical University Xinxiang Henan ChinaNational Clinical Research Center for Mental Disorders and Department of Psychiatry The Second Xiangya Hospital of Central South University Changsha Hunan ChinaDepartment of Psychiatry Qiqihar Medical University Qiqihar Heilongjiang ChinaDepartment of Psychiatry Qiqihar Medical University Qiqihar Heilongjiang ChinaHenan Key Laboratory of Biological Psychiatry The Second Affiliated Hospital of Xinxiang Medical University Xinxiang Henan ChinaDepartment of Psychiatry Qiqihar Medical University Qiqihar Heilongjiang ChinaDepartment of Psychiatry Qiqihar Medical University Qiqihar Heilongjiang ChinaDepartment of Psychiatry Qiqihar Medical University Qiqihar Heilongjiang ChinaDepartment of Psychiatry Qiqihar Medical University Qiqihar Heilongjiang ChinaDepartment of Radiology The Second Xiangya Hospital of Central South University Changsha Hunan ChinaNational Clinical Research Center for Mental Disorders and Department of Psychiatry The Second Xiangya Hospital of Central South University Changsha Hunan ChinaNational Clinical Research Center for Mental Disorders and Department of Psychiatry The Second Xiangya Hospital of Central South University Changsha Hunan ChinaHenan Key Laboratory of Biological Psychiatry The Second Affiliated Hospital of Xinxiang Medical University Xinxiang Henan ChinaAbstract Background Neuroimaging studies have revealed the role of the right dorsolateral prefrontal cortex (DLPFC) in the neurobiological mechanism of obsessive–compulsive disorder (OCD). However, only a few studies have examined the functional connectivity (FC) pattern of the right DLPFC at rest in OCD. Objective The aim of this research is to examine the FC patterns of the right DLPFC at rest in OCD. Methods Twenty‐eight medication‐free patients with OCD and 20 healthy controls underwent resting‐state functional magnetic resonance imaging. Seed‐based FC and support vector machine (SVM) were used to analyze the imaging data. Results The patients with OCD showed reduced FC values in the right middle temporal gyrus (MTG), right superior temporal gyrus, right ventral anterior cingulate cortex (vACC), and left Crus II. No brain regions showed a remarkable difference in FC values in patients with OCD after 8 weeks of medication treatment. The reduced right DLPFC–right MTG and right DLPFC–right vACC connectivities were correlated with the clinical symptoms of OCD. SVM results showed that reduced right DLPFC–right MTG connectivity at rest could predict the therapeutic response to OCD medication. Conclusions The findings highlight the important role of the right DLPFC in the pathophysiological mechanism of OCD.https://doi.org/10.1002/brb3.3333functional connectivityfunctional magnetic resonance imagingobsessive–compulsive disorderresting‐stateright dorsolateral prefrontal cortex |
| spellingShingle | Zhaoxi Zhong Yangpan Ou Yunhui Chen Ping Li Han Shi Dan Lv Cuicui Jia Tinghuizi Shang Lei Sun Ru Yang Xiaoping Wang Wenbin Guo Luxian Lv Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive–compulsive disorder Brain and Behavior functional connectivity functional magnetic resonance imaging obsessive–compulsive disorder resting‐state right dorsolateral prefrontal cortex |
| title | Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive–compulsive disorder |
| title_full | Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive–compulsive disorder |
| title_fullStr | Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive–compulsive disorder |
| title_full_unstemmed | Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive–compulsive disorder |
| title_short | Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive–compulsive disorder |
| title_sort | reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive compulsive disorder |
| topic | functional connectivity functional magnetic resonance imaging obsessive–compulsive disorder resting‐state right dorsolateral prefrontal cortex |
| url | https://doi.org/10.1002/brb3.3333 |
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