Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden
Objectives: To assess if mammographic density (MD) changes during neoadjuvant breast cancer treatment and is predictive of a pathological complete response (pCR). Methods: We prospectively included 200 breast cancer patients assigned to neoadjuvant chemotherapy (NACT) in the NeoDense study (2014–201...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S096097762030120X |
| _version_ | 1818229889691549696 |
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| author | Ida Skarping Daniel Förnvik Uffe Heide-Jørgensen Hanna Sartor Per Hall Sophia Zackrisson Signe Borgquist |
| author_facet | Ida Skarping Daniel Förnvik Uffe Heide-Jørgensen Hanna Sartor Per Hall Sophia Zackrisson Signe Borgquist |
| author_sort | Ida Skarping |
| collection | DOAJ |
| description | Objectives: To assess if mammographic density (MD) changes during neoadjuvant breast cancer treatment and is predictive of a pathological complete response (pCR). Methods: We prospectively included 200 breast cancer patients assigned to neoadjuvant chemotherapy (NACT) in the NeoDense study (2014–2019). Raw data mammograms were used to assess MD with a fully automated volumetric method and radiologists categorized MD using the Breast Imaging-Reporting and Data System (BI-RADS), 5th Edition. Logistic regression was used to calculate odds ratios (OR) for pCR comparing BI-RADS categories c vs. a, b, and d as well as with a 0.5% change in percent dense volume adjusting for baseline characteristics. Results: The overall median age was 53.1 years, and 48% of study participants were premenopausal pre-NACT. A total of 23% (N = 45) of the patients accomplished pCR following NACT. Patients with very dense breasts (BI-RADS d) were more likely to have a positive axillary lymph node status at diagnosis: 89% of the patients with very dense breasts compared to 72% in the entire cohort. A total of 74% of patients decreased their absolute dense volume during NACT. The likelihood of accomplishing pCR following NACT was independent of volumetric MD at diagnosis and change in volumetric MD during treatment. No trend was observed between decreasing density according to BI-RADS and the likelihood of accomplishing pCR following NACT. Conclusions: The majority of patients decreased their MD during NACT. We found no evidence of MD as a predictive marker of pCR in the neoadjuvant setting. |
| first_indexed | 2024-12-12T10:25:47Z |
| format | Article |
| id | doaj.art-a553cb26ae1f45268c33b7fc7fc7fb91 |
| institution | Directory Open Access Journal |
| issn | 1532-3080 |
| language | English |
| last_indexed | 2024-12-12T10:25:47Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj.art-a553cb26ae1f45268c33b7fc7fc7fb912022-12-22T00:27:28ZengElsevierBreast1532-30802020-10-01533341Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in SwedenIda Skarping0Daniel Förnvik1Uffe Heide-Jørgensen2Hanna Sartor3Per Hall4Sophia Zackrisson5Signe Borgquist6Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden; Corresponding author.Medical Radiation Physics, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, SwedenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, DenmarkDiagnostic Radiology, Department of Translational Medicine, Lund University, Skåne University Hospital, Lund and Malmö, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, SwedenDiagnostic Radiology, Department of Translational Medicine, Lund University, Skåne University Hospital, Lund and Malmö, SwedenDivision of Oncology and Pathology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden; Department of Oncology, Aarhus University Hospital, Aarhus, DenmarkObjectives: To assess if mammographic density (MD) changes during neoadjuvant breast cancer treatment and is predictive of a pathological complete response (pCR). Methods: We prospectively included 200 breast cancer patients assigned to neoadjuvant chemotherapy (NACT) in the NeoDense study (2014–2019). Raw data mammograms were used to assess MD with a fully automated volumetric method and radiologists categorized MD using the Breast Imaging-Reporting and Data System (BI-RADS), 5th Edition. Logistic regression was used to calculate odds ratios (OR) for pCR comparing BI-RADS categories c vs. a, b, and d as well as with a 0.5% change in percent dense volume adjusting for baseline characteristics. Results: The overall median age was 53.1 years, and 48% of study participants were premenopausal pre-NACT. A total of 23% (N = 45) of the patients accomplished pCR following NACT. Patients with very dense breasts (BI-RADS d) were more likely to have a positive axillary lymph node status at diagnosis: 89% of the patients with very dense breasts compared to 72% in the entire cohort. A total of 74% of patients decreased their absolute dense volume during NACT. The likelihood of accomplishing pCR following NACT was independent of volumetric MD at diagnosis and change in volumetric MD during treatment. No trend was observed between decreasing density according to BI-RADS and the likelihood of accomplishing pCR following NACT. Conclusions: The majority of patients decreased their MD during NACT. We found no evidence of MD as a predictive marker of pCR in the neoadjuvant setting.http://www.sciencedirect.com/science/article/pii/S096097762030120XBreast cancerMammographyBreast densityNeoadjuvant therapy |
| spellingShingle | Ida Skarping Daniel Förnvik Uffe Heide-Jørgensen Hanna Sartor Per Hall Sophia Zackrisson Signe Borgquist Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden Breast Breast cancer Mammography Breast density Neoadjuvant therapy |
| title | Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden |
| title_full | Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden |
| title_fullStr | Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden |
| title_full_unstemmed | Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden |
| title_short | Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden |
| title_sort | mammographic density changes during neoadjuvant breast cancer treatment neodense a prospective study in sweden |
| topic | Breast cancer Mammography Breast density Neoadjuvant therapy |
| url | http://www.sciencedirect.com/science/article/pii/S096097762030120X |
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