How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The endoplasmic reticulum aminopeptidases (E...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02463/full |
| _version_ | 1818285628150775808 |
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| author | José A. López de Castro |
| author_facet | José A. López de Castro |
| author_sort | José A. López de Castro |
| collection | DOAJ |
| description | Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 are also risk factors for these diseases. Since both enzymes are involved in the final processing steps of MHC-I ligands it is reasonable to assume that MHC-I-bound peptides play a significant pathogenetic role. This review will mainly focus on recent studies concerning the effects of ERAP1 and ERAP2 polymorphism and expression on shaping the peptidome of disease-associated MHC-I molecules in live cells. These studies will be discussed in the context of the distinct mechanisms and substrate preferences of both enzymes, their different patterns of genetic association with various diseases, the role of polymorphisms determining changes in enzymatic activity or expression levels, and the distinct peptidomes of disease-associated MHC-I allotypes. ERAP1 and ERAP2 polymorphism and expression induce significant changes in multiple MHC-I-bound peptidomes. These changes are MHC allotype-specific and, without excluding a degree of functional inter-dependence between both enzymes, reflect largely separate roles in their processing of MHC-I ligands. The studies reviewed here provide a molecular basis for the distinct patterns of genetic association of ERAP1 and ERAP2 with disease and for the pathogenetic role of peptides. The allotype-dependent alterations induced on distinct peptidomes may explain that the joint association of both enzymes and unrelated MHC-I alleles influence different pathological outcomes. |
| first_indexed | 2024-12-13T01:11:43Z |
| format | Article |
| id | doaj.art-a553f2b5227e439dac889d81a014845c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T01:11:43Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a553f2b5227e439dac889d81a014845c2022-12-22T00:04:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-10-01910.3389/fimmu.2018.02463415782How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I ProteinsJosé A. López de CastroFour inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 are also risk factors for these diseases. Since both enzymes are involved in the final processing steps of MHC-I ligands it is reasonable to assume that MHC-I-bound peptides play a significant pathogenetic role. This review will mainly focus on recent studies concerning the effects of ERAP1 and ERAP2 polymorphism and expression on shaping the peptidome of disease-associated MHC-I molecules in live cells. These studies will be discussed in the context of the distinct mechanisms and substrate preferences of both enzymes, their different patterns of genetic association with various diseases, the role of polymorphisms determining changes in enzymatic activity or expression levels, and the distinct peptidomes of disease-associated MHC-I allotypes. ERAP1 and ERAP2 polymorphism and expression induce significant changes in multiple MHC-I-bound peptidomes. These changes are MHC allotype-specific and, without excluding a degree of functional inter-dependence between both enzymes, reflect largely separate roles in their processing of MHC-I ligands. The studies reviewed here provide a molecular basis for the distinct patterns of genetic association of ERAP1 and ERAP2 with disease and for the pathogenetic role of peptides. The allotype-dependent alterations induced on distinct peptidomes may explain that the joint association of both enzymes and unrelated MHC-I alleles influence different pathological outcomes.https://www.frontiersin.org/article/10.3389/fimmu.2018.02463/fullMHCinflammatory diseasesERAPantigen processingankylosing spondylitisuveitis |
| spellingShingle | José A. López de Castro How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins Frontiers in Immunology MHC inflammatory diseases ERAP antigen processing ankylosing spondylitis uveitis |
| title | How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins |
| title_full | How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins |
| title_fullStr | How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins |
| title_full_unstemmed | How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins |
| title_short | How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins |
| title_sort | how erap1 and erap2 shape the peptidomes of disease associated mhc i proteins |
| topic | MHC inflammatory diseases ERAP antigen processing ankylosing spondylitis uveitis |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02463/full |
| work_keys_str_mv | AT josealopezdecastro howerap1anderap2shapethepeptidomesofdiseaseassociatedmhciproteins |