Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti‐Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation

Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti‐Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation

Abstract The increased levels of cyclic nucleotides (cGMP and cAMP) in enterocytes trigger intracellular mechanisms of ion and fluid secretion into the lumen, causing secretory diarrhea. Twelve novel pyridopyrimidines derived from 5‐(3,5‐bistrifluoromethylphenyl)‐1,3‐dimethyl‐5,11‐dihydro‐1H‐indeno[...

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Bibliographic Details
Main Authors: Dr. Tiago Zaminelli, Dr. Elisa Magli, Prof. Francesco Frecentese, Dr. Caroline H. Lescano, Dr. Rafael Campos, Dr. Irene Saccone, Dr. Angela Corvino, Dr. Paola Di Vaio, Dr. Flavia Giordano, Dr. Paolo Luciano, Prof. Ferdinando Fiorino, Prof. Elisa Perissutti, Prof. Vincenzo Santagada, Prof. Beatrice Severino, Prof. Giuseppe Caliendo, Prof. Gilberto De Nucci
Format: Article
Language:English
Published: Wiley-VCH 2019-04-01
Series:ChemistryOpen
Subjects:
pyridopyrimidines
diarrhea
cyclic nucleotides
drug discovery
structure-activity relationships
Online Access:https://doi.org/10.1002/open.201900060

Internet

https://doi.org/10.1002/open.201900060

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