Suppression of Inflamm-Aging by <i>Moringa oleifera</i> and <i>Zingiber officinale</i> Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence
Inflammation or inflamm-aging is a chronic low-grade inflammation that contributes to numerous types of degenerative diseases among the elderly and might be impeded by introducing an anti-inflammatory agent like <i>Moringa oleifera</i> Lam (moringa) and <i>Zingiber officinale</i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5867 |
| _version_ | 1797586255622438912 |
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| author | Nur Fatin Nabilah Mohd Sahardi Suzana Makpol |
| author_facet | Nur Fatin Nabilah Mohd Sahardi Suzana Makpol |
| author_sort | Nur Fatin Nabilah Mohd Sahardi |
| collection | DOAJ |
| description | Inflammation or inflamm-aging is a chronic low-grade inflammation that contributes to numerous types of degenerative diseases among the elderly and might be impeded by introducing an anti-inflammatory agent like <i>Moringa oleifera</i> Lam (moringa) and <i>Zingiber officinale</i> Roscoe (ginger). Therefore, this paper aims to review the role of moringa and ginger in suppressing inflamm-aging to prevent degenerative diseases. Various peer-reviewed publications were searched and downloaded using the reputed search engine “Pubmed” and “Google Scholar”. These materials were reviewed and tabulated. A comparison between these previous findings was made based on the mechanism of action of moringa and ginger against degenerative diseases, focusing on their anti-inflammatory properties. Many studies have reported the efficacy of moringa and ginger in type 2 diabetes mellitus, neurodegenerative disease, cardiovascular disease, cancer, and kidney disease by reducing inflammatory cytokines activities, mainly of TNF-α and IL-6. They also enhanced the activity of antioxidant enzymes, including catalase, glutathione, and superoxide dismutase. The anti-inflammatory activities can be seen by inhibiting NF-κβ activity. Thus, the anti-inflammatory potential of moringa and ginger in various types of degenerative diseases due to inflamm-aging has been shown in many recent types of research. |
| first_indexed | 2024-03-11T00:20:45Z |
| format | Article |
| id | doaj.art-a55444dd573b4b9c9acf65bcb2fb3667 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:20:45Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a55444dd573b4b9c9acf65bcb2fb36672023-11-18T23:19:55ZengMDPI AGMolecules1420-30492023-08-012815586710.3390/molecules28155867Suppression of Inflamm-Aging by <i>Moringa oleifera</i> and <i>Zingiber officinale</i> Roscoe in the Prevention of Degenerative Diseases: A Review of Current EvidenceNur Fatin Nabilah Mohd Sahardi0Suzana Makpol1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaInflammation or inflamm-aging is a chronic low-grade inflammation that contributes to numerous types of degenerative diseases among the elderly and might be impeded by introducing an anti-inflammatory agent like <i>Moringa oleifera</i> Lam (moringa) and <i>Zingiber officinale</i> Roscoe (ginger). Therefore, this paper aims to review the role of moringa and ginger in suppressing inflamm-aging to prevent degenerative diseases. Various peer-reviewed publications were searched and downloaded using the reputed search engine “Pubmed” and “Google Scholar”. These materials were reviewed and tabulated. A comparison between these previous findings was made based on the mechanism of action of moringa and ginger against degenerative diseases, focusing on their anti-inflammatory properties. Many studies have reported the efficacy of moringa and ginger in type 2 diabetes mellitus, neurodegenerative disease, cardiovascular disease, cancer, and kidney disease by reducing inflammatory cytokines activities, mainly of TNF-α and IL-6. They also enhanced the activity of antioxidant enzymes, including catalase, glutathione, and superoxide dismutase. The anti-inflammatory activities can be seen by inhibiting NF-κβ activity. Thus, the anti-inflammatory potential of moringa and ginger in various types of degenerative diseases due to inflamm-aging has been shown in many recent types of research.https://www.mdpi.com/1420-3049/28/15/5867anti-inflammatory agentsdegenerative disease<i>Moringa oleifera</i> Laminflamm-aging and <i>Zingiber officinale</i> Roscoe |
| spellingShingle | Nur Fatin Nabilah Mohd Sahardi Suzana Makpol Suppression of Inflamm-Aging by <i>Moringa oleifera</i> and <i>Zingiber officinale</i> Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence Molecules anti-inflammatory agents degenerative disease <i>Moringa oleifera</i> Lam inflamm-aging and <i>Zingiber officinale</i> Roscoe |
| title | Suppression of Inflamm-Aging by <i>Moringa oleifera</i> and <i>Zingiber officinale</i> Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence |
| title_full | Suppression of Inflamm-Aging by <i>Moringa oleifera</i> and <i>Zingiber officinale</i> Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence |
| title_fullStr | Suppression of Inflamm-Aging by <i>Moringa oleifera</i> and <i>Zingiber officinale</i> Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence |
| title_full_unstemmed | Suppression of Inflamm-Aging by <i>Moringa oleifera</i> and <i>Zingiber officinale</i> Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence |
| title_short | Suppression of Inflamm-Aging by <i>Moringa oleifera</i> and <i>Zingiber officinale</i> Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence |
| title_sort | suppression of inflamm aging by i moringa oleifera i and i zingiber officinale i roscoe in the prevention of degenerative diseases a review of current evidence |
| topic | anti-inflammatory agents degenerative disease <i>Moringa oleifera</i> Lam inflamm-aging and <i>Zingiber officinale</i> Roscoe |
| url | https://www.mdpi.com/1420-3049/28/15/5867 |
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