The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic
Abstract Background We investigated the relevance of various imaging markers for the clinical trajectory of cerebral amyloid angiopathy (CAA) patients in a memory clinic. Methods A total of 226 patients with probable CAA were included in this study with a mean follow-up period of 3.5 ± 2.7 years. Al...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Alzheimer’s Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13195-023-01161-5 |
| _version_ | 1797952640504561664 |
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| author | Hyemin Jang Min Young Chun Hee Jin Kim Duk L. Na Sang Won Seo |
| author_facet | Hyemin Jang Min Young Chun Hee Jin Kim Duk L. Na Sang Won Seo |
| author_sort | Hyemin Jang |
| collection | DOAJ |
| description | Abstract Background We investigated the relevance of various imaging markers for the clinical trajectory of cerebral amyloid angiopathy (CAA) patients in a memory clinic. Methods A total of 226 patients with probable CAA were included in this study with a mean follow-up period of 3.5 ± 2.7 years. Although all had more than one follow-up visit, 173 underwent follow-up Mini-Mental Status Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SB) ranging from 2 to 15 time points. Among 226, 122 patients underwent amyloid-β (Aβ) PET imaging. The prevalence of intracerebral hemorrhage (ICH) and its imaging predictors was investigated. The effects of CAA imaging markers and Aβ PET positivity on longitudinal cognition based on the MMSE and CDR-SB were evaluated using mixed effects models. Results During the follow-up, 10 (4.4%) patients developed ICH: cortical superficial siderosis (cSS; hazard ratio [HR], 6.45) and previous lobar ICH (HR, 4.9), but lobar cerebral microbleeds (CMBs) were not predictors of ICH development. The presence of CMIs (p = 0.045) and Aβ positivity (p = 0.002) were associated with worse MMSE trajectory in CAA patients. Regarding CDR-SB trajectory, only Aβ positivity was marginally associated with worse longitudinal change (p = 0.050). Conclusion The results of the present study indicated that various imaging markers in CAA patients have different clinical relevance and predictive values for further clinical courses. |
| first_indexed | 2024-04-10T22:49:37Z |
| format | Article |
| id | doaj.art-a555f68e01a443fb93ec9e443fbb2293 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-04-10T22:49:37Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-a555f68e01a443fb93ec9e443fbb22932023-01-15T12:06:12ZengBMCAlzheimer’s Research & Therapy1758-91932023-01-011511910.1186/s13195-023-01161-5The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinicHyemin Jang0Min Young Chun1Hee Jin Kim2Duk L. Na3Sang Won Seo4Samsung Alzheimer’s Convergence Research Center, Samsung Medical CenterDepartments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineSamsung Alzheimer’s Convergence Research Center, Samsung Medical CenterAbstract Background We investigated the relevance of various imaging markers for the clinical trajectory of cerebral amyloid angiopathy (CAA) patients in a memory clinic. Methods A total of 226 patients with probable CAA were included in this study with a mean follow-up period of 3.5 ± 2.7 years. Although all had more than one follow-up visit, 173 underwent follow-up Mini-Mental Status Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SB) ranging from 2 to 15 time points. Among 226, 122 patients underwent amyloid-β (Aβ) PET imaging. The prevalence of intracerebral hemorrhage (ICH) and its imaging predictors was investigated. The effects of CAA imaging markers and Aβ PET positivity on longitudinal cognition based on the MMSE and CDR-SB were evaluated using mixed effects models. Results During the follow-up, 10 (4.4%) patients developed ICH: cortical superficial siderosis (cSS; hazard ratio [HR], 6.45) and previous lobar ICH (HR, 4.9), but lobar cerebral microbleeds (CMBs) were not predictors of ICH development. The presence of CMIs (p = 0.045) and Aβ positivity (p = 0.002) were associated with worse MMSE trajectory in CAA patients. Regarding CDR-SB trajectory, only Aβ positivity was marginally associated with worse longitudinal change (p = 0.050). Conclusion The results of the present study indicated that various imaging markers in CAA patients have different clinical relevance and predictive values for further clinical courses.https://doi.org/10.1186/s13195-023-01161-5Cerebral amyloid angiopathyPrognosisCognitionAmyloid βMicrobleedCortical superficial siderosis |
| spellingShingle | Hyemin Jang Min Young Chun Hee Jin Kim Duk L. Na Sang Won Seo The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic Alzheimer’s Research & Therapy Cerebral amyloid angiopathy Prognosis Cognition Amyloid β Microbleed Cortical superficial siderosis |
| title | The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic |
| title_full | The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic |
| title_fullStr | The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic |
| title_full_unstemmed | The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic |
| title_short | The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic |
| title_sort | effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy a longitudinal study in a memory clinic |
| topic | Cerebral amyloid angiopathy Prognosis Cognition Amyloid β Microbleed Cortical superficial siderosis |
| url | https://doi.org/10.1186/s13195-023-01161-5 |
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