Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia
Objective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). Methods: Placental tissues and maternal blood samples from...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-04-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2017.1291673 |
| _version_ | 1797681598098833408 |
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| author | Laura Ehrlich Alice Hoeller Michaela Golic Florian Herse Frank H. Perschel Wolfgang Henrich Ralf Dechend Berthold Huppertz Stefan Verlohren |
| author_facet | Laura Ehrlich Alice Hoeller Michaela Golic Florian Herse Frank H. Perschel Wolfgang Henrich Ralf Dechend Berthold Huppertz Stefan Verlohren |
| author_sort | Laura Ehrlich |
| collection | DOAJ |
| description | Objective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). Methods: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. Results: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased. Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels. |
| first_indexed | 2024-03-11T23:47:16Z |
| format | Article |
| id | doaj.art-a558c179fb464aae8e5fb7ac2cf3f6b3 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:47:16Z |
| publishDate | 2017-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-a558c179fb464aae8e5fb7ac2cf3f6b32023-09-19T09:24:42ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652017-04-0136217518510.1080/10641955.2017.12916731291673Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsiaLaura Ehrlich0Alice Hoeller1Michaela Golic2Florian Herse3Frank H. Perschel4Wolfgang Henrich5Ralf Dechend6Berthold Huppertz7Stefan Verlohren8Campus Virchow-Clinic, Charite´ University MedicineCampus Virchow-Clinic, Charite´ University MedicineCampus Virchow-Clinic, Charite´ University MedicineMedical Faculty of the Charité and Max-Delbrueck Center for Molecular MedicineCharité University Medicine Berlin und Labor Berlin – Charité Vivantes GmbHCampus Virchow-Clinic, Charite´ University MedicineMedical Faculty of the Charité and Max-Delbrueck Center for Molecular MedicineInstitute of Cell Biology, Histology and Embryology, Medical University of GrazCampus Virchow-Clinic, Charite´ University MedicineObjective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). Methods: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. Results: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased. Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.http://dx.doi.org/10.1080/10641955.2017.1291673preeclampsiaintra uterine growth restrictionplacental growth factorplgfsouble fms-like tyrosine kinasesflt1 |
| spellingShingle | Laura Ehrlich Alice Hoeller Michaela Golic Florian Herse Frank H. Perschel Wolfgang Henrich Ralf Dechend Berthold Huppertz Stefan Verlohren Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia Hypertension in Pregnancy preeclampsia intra uterine growth restriction placental growth factor plgf souble fms-like tyrosine kinase sflt1 |
| title | Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia |
| title_full | Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia |
| title_fullStr | Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia |
| title_full_unstemmed | Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia |
| title_short | Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia |
| title_sort | increased placental sflt 1 but unchanged plgf expression in late onset preeclampsia |
| topic | preeclampsia intra uterine growth restriction placental growth factor plgf souble fms-like tyrosine kinase sflt1 |
| url | http://dx.doi.org/10.1080/10641955.2017.1291673 |
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