Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6
Objective Reliable biomarkers of delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning are lacking. This study investigated the associations between potential serum markers and the development of DNS after acute CO poisoning. Methods Retrospective chart reviews were co...
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| Format: | Article |
| Language: | English |
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The Korean Society of Emergency Medicine
2018-09-01
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| Series: | Clinical and Experimental Emergency Medicine |
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| Online Access: | http://www.ceemjournal.org/upload/pdf/ceem-17-217.pdf |
| _version_ | 1797895636232699904 |
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| author | Hyukhoon Kim Sangchun Choi Eunjung Park Eunhui Yoon Younggi Min Samsun Lampotang |
| author_facet | Hyukhoon Kim Sangchun Choi Eunjung Park Eunhui Yoon Younggi Min Samsun Lampotang |
| author_sort | Hyukhoon Kim |
| collection | DOAJ |
| description | Objective Reliable biomarkers of delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning are lacking. This study investigated the associations between potential serum markers and the development of DNS after acute CO poisoning. Methods Retrospective chart reviews were conducted for patients diagnosed with acute CO poisoning during a 28-month period. The patients were divided into two groups according to the presence or absence of having developed DNS. Multivariate analysis was performed to identify predictors of DNS after CO poisoning. Results Of a total of 102 patients, 10 (9.8%) developed DNS. The levels of serum osmolarity, S100B protein, and serum lactate, as well as serum anion gap, were statistically significant in univariate analysis. Multiple logistic regression analysis showed that anion gap (adjusted odds ratio [AOR], 1.36; 95% confidence interval [CI], 1.11 to 1.88), serum lactate level (AOR, 1.74; 95% CI, 1.26 to 2.75), and serum S100B protein level ([AOR, 7.02×105; 95% CI, 4.56×102 to 9.00×1010] in model 1, [AOR, 3.69×105; 95% CI, 2.49×102 to 2.71×1011] in model 2) were independently associated with DNS development. Conclusion Based on our preliminary results, serum lactate level, serum anion gap, and serum S100B protein level in the emergency department could be informative predictors of DNS development in patients with acute CO poisoning. These markers might have the potential to improve early recognition of DNS in patients with acute CO poisoning. |
| first_indexed | 2024-04-10T07:29:03Z |
| format | Article |
| id | doaj.art-a559114b153649debaf0ac68599dbfe1 |
| institution | Directory Open Access Journal |
| issn | 2383-4625 |
| language | English |
| last_indexed | 2024-04-10T07:29:03Z |
| publishDate | 2018-09-01 |
| publisher | The Korean Society of Emergency Medicine |
| record_format | Article |
| series | Clinical and Experimental Emergency Medicine |
| spelling | doaj.art-a559114b153649debaf0ac68599dbfe12023-02-24T01:32:12ZengThe Korean Society of Emergency MedicineClinical and Experimental Emergency Medicine2383-46252018-09-015318519110.15441/ceem.17.217194Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6Hyukhoon Kim0Sangchun Choi1Eunjung Park2Eunhui Yoon3Younggi Min4Samsun Lampotang5 Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea Center for Safety, Simulation & Advanced Learning Technologies, University of Florida, Gainesville, FL, USA Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea Center for Safety, Simulation & Advanced Learning Technologies, University of Florida, Gainesville, FL, USAObjective Reliable biomarkers of delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning are lacking. This study investigated the associations between potential serum markers and the development of DNS after acute CO poisoning. Methods Retrospective chart reviews were conducted for patients diagnosed with acute CO poisoning during a 28-month period. The patients were divided into two groups according to the presence or absence of having developed DNS. Multivariate analysis was performed to identify predictors of DNS after CO poisoning. Results Of a total of 102 patients, 10 (9.8%) developed DNS. The levels of serum osmolarity, S100B protein, and serum lactate, as well as serum anion gap, were statistically significant in univariate analysis. Multiple logistic regression analysis showed that anion gap (adjusted odds ratio [AOR], 1.36; 95% confidence interval [CI], 1.11 to 1.88), serum lactate level (AOR, 1.74; 95% CI, 1.26 to 2.75), and serum S100B protein level ([AOR, 7.02×105; 95% CI, 4.56×102 to 9.00×1010] in model 1, [AOR, 3.69×105; 95% CI, 2.49×102 to 2.71×1011] in model 2) were independently associated with DNS development. Conclusion Based on our preliminary results, serum lactate level, serum anion gap, and serum S100B protein level in the emergency department could be informative predictors of DNS development in patients with acute CO poisoning. These markers might have the potential to improve early recognition of DNS in patients with acute CO poisoning.http://www.ceemjournal.org/upload/pdf/ceem-17-217.pdfacid-base equilibriumlactic acidcarbon monoxide poisoningneurotoxicity syndromesosmolar concentration |
| spellingShingle | Hyukhoon Kim Sangchun Choi Eunjung Park Eunhui Yoon Younggi Min Samsun Lampotang Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6 Clinical and Experimental Emergency Medicine acid-base equilibrium lactic acid carbon monoxide poisoning neurotoxicity syndromes osmolar concentration |
| title | Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6 |
| title_full | Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6 |
| title_fullStr | Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6 |
| title_full_unstemmed | Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6 |
| title_short | Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6 |
| title_sort | serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning anion gap lactate osmolarity s100b protein and interleukin 6 |
| topic | acid-base equilibrium lactic acid carbon monoxide poisoning neurotoxicity syndromes osmolar concentration |
| url | http://www.ceemjournal.org/upload/pdf/ceem-17-217.pdf |
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