Synthesis and pharmacological evaluation of fluoro/chloro-substituted acetyl and benzoyl esters of quinine as antimalarial agents

Synthesis and pharmacological evaluation of fluoro/chloro-substituted acetyl and benzoyl esters of quinine as antimalarial agents

After establishment of the pharmacokinetic and toxicological profile of quinine derivatives using in silico approaches, this study reports the synthesis of new acetyl and benzoyl esters of quinine bearing one or more fluorine or chlorine atoms on the acetyl/benzoyl moiety. The antimalarial activity...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Jean-Gonfi Mvondo Mbala, Dani Thierry Mawete, Alain Nanikafuako Makiese, Prosper Lwanzo Kwiraviwe, Bibiche Kuyubuka Pangu, Eric Buini Nguimi, Richard Cimanga Kanyanga, Luc Pieters, Gilles Degotte, Michel Frederich, Aristote Matondo, Natascha Van Pelt, Guy Caljon, Bernard Pirotte, Blaise Mbala Mavinga, Sylvie-Mireille Bambi-Nyanguile
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Elsevier 2024-01-01
Цуврал:Results in Chemistry
Нөхцлүүд:
Quinine
Antiplasmodial activity
Plasmodium falciparum
Acetyl derivatives
Benzoyl derivatives
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S2211715623005234

Интернэт

http://www.sciencedirect.com/science/article/pii/S2211715623005234

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