Identification of Interleukin-8-Reducing Lead Compounds Based on SAR Studies on Dihydrochalcone-Related Compounds in Human Gingival Fibroblasts (HGF-1 cells) In Vitro

Identification of Interleukin-8-Reducing Lead Compounds Based on SAR Studies on Dihydrochalcone-Related Compounds in Human Gingival Fibroblasts (HGF-1 cells) In Vitro

<b>Background:</b> In order to identify potential activities against periodontal diseases, eighteen dihydrochalcones and structurally related compounds were tested in an established biological in vitro cell model of periodontal inflammation using human gingival fibroblasts (HGF-1 cells)....

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Bibliographic Details
Main Authors: Katharina Schueller, Joachim Hans, Stefanie Pfeiffer, Jessica Walker, Jakob P. Ley, Veronika Somoza
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
structure–activity relationship
inflammation
dihydrochalcones
il-8
hgf-1 cells
Online Access:https://www.mdpi.com/1420-3049/25/6/1382

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