Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system
Abstract Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy (SCOS) is a technique that has been recently developed to measure CBF, but the use of SCOS to measure human brain function at large source-detector separations with comparable or greater sensitivity...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05211-4 |
| _version_ | 1797557159705182208 |
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| author | Byungchan Kim Sharvari Zilpelwar Edbert J. Sie Francesco Marsili Bernhard Zimmermann David A. Boas Xiaojun Cheng |
| author_facet | Byungchan Kim Sharvari Zilpelwar Edbert J. Sie Francesco Marsili Bernhard Zimmermann David A. Boas Xiaojun Cheng |
| author_sort | Byungchan Kim |
| collection | DOAJ |
| description | Abstract Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy (SCOS) is a technique that has been recently developed to measure CBF, but the use of SCOS to measure human brain function at large source-detector separations with comparable or greater sensitivity to cerebral rather than extracerebral blood flow has not been demonstrated. We describe a fiber-based SCOS system capable of measuring human brain activation induced CBF changes at 33 mm source detector separations using CMOS detectors. The system implements a pulsing strategy to improve the photon flux and uses a data processing pipeline to improve measurement accuracy. We show that SCOS outperforms the current leading optical modality for measuring CBF, i.e. diffuse correlation spectroscopy (DCS), achieving more than 10x SNR improvement at a similar financial cost. Fiber-based SCOS provides an alternative approach to functional neuroimaging for cognitive neuroscience and health science applications. |
| first_indexed | 2024-03-10T17:13:24Z |
| format | Article |
| id | doaj.art-a55aac26ae064418bd3efbfe2b4abf30 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-10T17:13:24Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a55aac26ae064418bd3efbfe2b4abf302023-11-20T10:36:10ZengNature PortfolioCommunications Biology2399-36422023-08-016111010.1038/s42003-023-05211-4Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy systemByungchan Kim0Sharvari Zilpelwar1Edbert J. Sie2Francesco Marsili3Bernhard Zimmermann4David A. Boas5Xiaojun Cheng6Neurophotonics Center, Department of Biomedical Engineering, Boston UniversityNeurophotonics Center, Department of Biomedical Engineering, Boston UniversityReality Labs Research, Meta Platforms IncReality Labs Research, Meta Platforms IncNeurophotonics Center, Department of Biomedical Engineering, Boston UniversityNeurophotonics Center, Department of Biomedical Engineering, Boston UniversityNeurophotonics Center, Department of Biomedical Engineering, Boston UniversityAbstract Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy (SCOS) is a technique that has been recently developed to measure CBF, but the use of SCOS to measure human brain function at large source-detector separations with comparable or greater sensitivity to cerebral rather than extracerebral blood flow has not been demonstrated. We describe a fiber-based SCOS system capable of measuring human brain activation induced CBF changes at 33 mm source detector separations using CMOS detectors. The system implements a pulsing strategy to improve the photon flux and uses a data processing pipeline to improve measurement accuracy. We show that SCOS outperforms the current leading optical modality for measuring CBF, i.e. diffuse correlation spectroscopy (DCS), achieving more than 10x SNR improvement at a similar financial cost. Fiber-based SCOS provides an alternative approach to functional neuroimaging for cognitive neuroscience and health science applications.https://doi.org/10.1038/s42003-023-05211-4 |
| spellingShingle | Byungchan Kim Sharvari Zilpelwar Edbert J. Sie Francesco Marsili Bernhard Zimmermann David A. Boas Xiaojun Cheng Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system Communications Biology |
| title | Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system |
| title_full | Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system |
| title_fullStr | Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system |
| title_full_unstemmed | Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system |
| title_short | Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system |
| title_sort | measuring human cerebral blood flow and brain function with fiber based speckle contrast optical spectroscopy system |
| url | https://doi.org/10.1038/s42003-023-05211-4 |
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