The intriguing roles of Siglec family members in the tumor microenvironment
Abstract Sialic acid-binding receptors are expressed on the surfaces of a variety of immune cells and have complex and diverse immunoregulatory functions in health and diseases. Recent studies have shown that Siglecs could play diverse immune and nonimmune regulatory roles in the tumor microenvironm...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-022-00369-1 |
| _version_ | 1828748831465930752 |
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| author | Kui-Ying Jiang Li-Li Qi Fu-Biao Kang Ling Wang |
| author_facet | Kui-Ying Jiang Li-Li Qi Fu-Biao Kang Ling Wang |
| author_sort | Kui-Ying Jiang |
| collection | DOAJ |
| description | Abstract Sialic acid-binding receptors are expressed on the surfaces of a variety of immune cells and have complex and diverse immunoregulatory functions in health and diseases. Recent studies have shown that Siglecs could play diverse immune and nonimmune regulatory roles in the tumor microenvironment (TME) and participate in tumor progression through various mechanisms, such as regulating tumor growth and metastasis, mediating the inflammatory response, and promoting tumor immune escape, thereby affecting the prognoses and outcomes of patients. However, depending on the cell type in which they are expressed, each Siglec member binds to corresponding ligands in the microenvironment milieu to drive diverse cell physiological and pathological processes in tumors. Therefore, we herein summarize the expression spectra and functions of the Siglec family in human diseases, particularly cancer, and highlight the possibility of therapeutic interventions targeting the TME in the future. |
| first_indexed | 2024-12-10T03:29:13Z |
| format | Article |
| id | doaj.art-a55ae0fc119949c387b7688e27ef6108 |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-12-10T03:29:13Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-a55ae0fc119949c387b7688e27ef61082022-12-22T02:03:51ZengBMCBiomarker Research2050-77712022-04-0110111410.1186/s40364-022-00369-1The intriguing roles of Siglec family members in the tumor microenvironmentKui-Ying Jiang0Li-Li Qi1Fu-Biao Kang2Ling Wang3Department of Orthopedic Oncology, the Third Hospital of Hebei Medical UniversityExperimental Center for Teaching of Hebei Medical UniversityThe Liver Disease Center of PLA, the 980Th Hospital of PLA Joint Logistics Support ForceDepartment of Orthopedic Oncology, the Third Hospital of Hebei Medical UniversityAbstract Sialic acid-binding receptors are expressed on the surfaces of a variety of immune cells and have complex and diverse immunoregulatory functions in health and diseases. Recent studies have shown that Siglecs could play diverse immune and nonimmune regulatory roles in the tumor microenvironment (TME) and participate in tumor progression through various mechanisms, such as regulating tumor growth and metastasis, mediating the inflammatory response, and promoting tumor immune escape, thereby affecting the prognoses and outcomes of patients. However, depending on the cell type in which they are expressed, each Siglec member binds to corresponding ligands in the microenvironment milieu to drive diverse cell physiological and pathological processes in tumors. Therefore, we herein summarize the expression spectra and functions of the Siglec family in human diseases, particularly cancer, and highlight the possibility of therapeutic interventions targeting the TME in the future.https://doi.org/10.1186/s40364-022-00369-1SiglecsTumor microenvironmentImmune regulation |
| spellingShingle | Kui-Ying Jiang Li-Li Qi Fu-Biao Kang Ling Wang The intriguing roles of Siglec family members in the tumor microenvironment Biomarker Research Siglecs Tumor microenvironment Immune regulation |
| title | The intriguing roles of Siglec family members in the tumor microenvironment |
| title_full | The intriguing roles of Siglec family members in the tumor microenvironment |
| title_fullStr | The intriguing roles of Siglec family members in the tumor microenvironment |
| title_full_unstemmed | The intriguing roles of Siglec family members in the tumor microenvironment |
| title_short | The intriguing roles of Siglec family members in the tumor microenvironment |
| title_sort | intriguing roles of siglec family members in the tumor microenvironment |
| topic | Siglecs Tumor microenvironment Immune regulation |
| url | https://doi.org/10.1186/s40364-022-00369-1 |
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