Solidagenone from <i>Solidago chilensis</i> Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway
Anti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of the available drugs make it necessary to search for new anti-inflammatory drugs. Here, we investigated the anti-inflammatory activity of solidagenone. Initially, we obser...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/17/3/273 |
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| author | Ivanilson Pimenta Santos Laís Peres Silva Dahara Keyse Carvalho Silva Bruna Padilha Zurita Claro dos Reis Temistocles Barroso de Oliveira Andressa Maia Kelly Edivaldo dos Santos Rodrigues Claudia Valeria Campos de Souza José Fernando Oliveira-Costa Simone Sacramento Valverde Osvaldo Andrade Santos-Filho Milena Botelho Pereira Soares Cássio Santana Meira |
| author_facet | Ivanilson Pimenta Santos Laís Peres Silva Dahara Keyse Carvalho Silva Bruna Padilha Zurita Claro dos Reis Temistocles Barroso de Oliveira Andressa Maia Kelly Edivaldo dos Santos Rodrigues Claudia Valeria Campos de Souza José Fernando Oliveira-Costa Simone Sacramento Valverde Osvaldo Andrade Santos-Filho Milena Botelho Pereira Soares Cássio Santana Meira |
| author_sort | Ivanilson Pimenta Santos |
| collection | DOAJ |
| description | Anti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of the available drugs make it necessary to search for new anti-inflammatory drugs. Here, we investigated the anti-inflammatory activity of solidagenone. Initially, we observed that a single dose of 30, 60, or 90 mg/kg of solidagenone did not result in mortality or elicit any discernible signs of toxicity in mice. At the same doses, solidagenone promoted a significant reduction in the migration of neutrophils in an acute peritonitis model and decreased mortality in a lipopolysaccharide-induced endotoxic shock model. Interestingly, treatment with solidagenone conferred a protective effect against leukopenia and thrombocytopenia, hematological disorders commonly observed in sepsis conditions. In addition, treatment with all the doses of solidagenone promoted a significant reduction in nitric oxide, TNF-α, and IL-1β levels relative to the LPS-stimulated vehicle-treated cultures. Furthermore, gene expression and in silico analyses also supported the modulation of the NF-<i>κ</i>B pathway by solidagenone. Finally, in silico pharmacokinetics predictions indicated a favorable drugability profile for solidagenone. Taken together, the findings of the present investigation show that solidagenone exhibits significant anti-inflammatory properties in acute experimental models, potentially through the modulation of the NF-κB signaling pathway. |
| first_indexed | 2024-04-24T17:56:19Z |
| format | Article |
| id | doaj.art-a55b3832f4bc47aabc52d839a442b1d9 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-04-24T17:56:19Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-a55b3832f4bc47aabc52d839a442b1d92024-03-27T13:59:09ZengMDPI AGPharmaceuticals1424-82472024-02-0117327310.3390/ph17030273Solidagenone from <i>Solidago chilensis</i> Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling PathwayIvanilson Pimenta Santos0Laís Peres Silva1Dahara Keyse Carvalho Silva2Bruna Padilha Zurita Claro dos Reis3Temistocles Barroso de Oliveira4Andressa Maia Kelly5Edivaldo dos Santos Rodrigues6Claudia Valeria Campos de Souza7José Fernando Oliveira-Costa8Simone Sacramento Valverde9Osvaldo Andrade Santos-Filho10Milena Botelho Pereira Soares11Cássio Santana Meira12Gonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, BrazilPharmaceutical Technology Institute—FarManguinhos, Natural Products Department, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro 21041-250, RJ, BrazilPharmaceutical Technology Institute—FarManguinhos, Natural Products Department, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro 21041-250, RJ, BrazilLaboratory of Molecular Modeling and Computational Structural Biology, Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, BrazilLaboratory of Molecular Modeling and Computational Structural Biology, Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, BrazilCenter for Infusions and Specialized Medicines of Bahia, Bahia State Health Department, Salvador 41745-900, BA, BrazilPharmaceutical Technology Institute—FarManguinhos, Natural Products Department, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro 21041-250, RJ, BrazilLaboratory of Molecular Modeling and Computational Structural Biology, Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador 40296-710, BA, BrazilAnti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of the available drugs make it necessary to search for new anti-inflammatory drugs. Here, we investigated the anti-inflammatory activity of solidagenone. Initially, we observed that a single dose of 30, 60, or 90 mg/kg of solidagenone did not result in mortality or elicit any discernible signs of toxicity in mice. At the same doses, solidagenone promoted a significant reduction in the migration of neutrophils in an acute peritonitis model and decreased mortality in a lipopolysaccharide-induced endotoxic shock model. Interestingly, treatment with solidagenone conferred a protective effect against leukopenia and thrombocytopenia, hematological disorders commonly observed in sepsis conditions. In addition, treatment with all the doses of solidagenone promoted a significant reduction in nitric oxide, TNF-α, and IL-1β levels relative to the LPS-stimulated vehicle-treated cultures. Furthermore, gene expression and in silico analyses also supported the modulation of the NF-<i>κ</i>B pathway by solidagenone. Finally, in silico pharmacokinetics predictions indicated a favorable drugability profile for solidagenone. Taken together, the findings of the present investigation show that solidagenone exhibits significant anti-inflammatory properties in acute experimental models, potentially through the modulation of the NF-κB signaling pathway.https://www.mdpi.com/1424-8247/17/3/273solidagenoneinflammationendotoxic shockNF-κB |
| spellingShingle | Ivanilson Pimenta Santos Laís Peres Silva Dahara Keyse Carvalho Silva Bruna Padilha Zurita Claro dos Reis Temistocles Barroso de Oliveira Andressa Maia Kelly Edivaldo dos Santos Rodrigues Claudia Valeria Campos de Souza José Fernando Oliveira-Costa Simone Sacramento Valverde Osvaldo Andrade Santos-Filho Milena Botelho Pereira Soares Cássio Santana Meira Solidagenone from <i>Solidago chilensis</i> Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway Pharmaceuticals solidagenone inflammation endotoxic shock NF-κB |
| title | Solidagenone from <i>Solidago chilensis</i> Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway |
| title_full | Solidagenone from <i>Solidago chilensis</i> Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway |
| title_fullStr | Solidagenone from <i>Solidago chilensis</i> Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway |
| title_full_unstemmed | Solidagenone from <i>Solidago chilensis</i> Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway |
| title_short | Solidagenone from <i>Solidago chilensis</i> Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway |
| title_sort | solidagenone from i solidago chilensis i meyen protects against acute peritonitis and lipopolysaccharide induced shock by regulating nf κb signaling pathway |
| topic | solidagenone inflammation endotoxic shock NF-κB |
| url | https://www.mdpi.com/1424-8247/17/3/273 |
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