Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study
Maternal short-chain fatty acids (SCFAs) play a critical role in fetal development and metabolic programming. However, an important gap in the analysis of such relationships is the lack of reference values in pregnant women. Therefore, we establish serum SCFA percentile reference ranges both early a...
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MDPI AG
2022-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/18/3798 |
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| author | Carla Martín-Grau Andrés Díaz-López Estefania Aparicio Victoria Arija |
| author_facet | Carla Martín-Grau Andrés Díaz-López Estefania Aparicio Victoria Arija |
| author_sort | Carla Martín-Grau |
| collection | DOAJ |
| description | Maternal short-chain fatty acids (SCFAs) play a critical role in fetal development and metabolic programming. However, an important gap in the analysis of such relationships is the lack of reference values in pregnant women. Therefore, we establish serum SCFA percentile reference ranges both early and later in pregnancy in a population from a Mediterranean region of Northern Spain. A population-based follow-up study involving 455 healthy pregnant women (mean age 30.6 ± 5.0 years) from the ECLIPSES study is conducted. Sociodemographic, obstetric, anthropometric, lifestyle, dietary variables and blood samples were collected in the first and third trimesters. Serum SCFA concentrations were measured by LC-MS/MS. The 2.5/97.5 percentiles of the reference interval for serum acetic, propionic, isobutyric, and butyric acids were 16.4/103.8 µmol/L, 2.1/5.8 µmol/L, 0.16/1.01 µmol/L and 0.32/1.67 µmol/L in the first trimester of pregnancy, respectively. In the third trimester, butyrate levels increased with most of the maternal factors and categories studied, while acetic acid and isobutyric acid decreased only in some maternal categories. Propionic acid was not affected by maternal factors. Reference ranges did not vary with maternal age, body weight, social class or diet, but decreased with smoking, high physical activity, low BMI and primiparity. This study establishes for the first-time SCFAs reference ranges in serum for women in our region in both early and late pregnancy. This information can be useful to monitor pregnancy follow-up and detect risk values. |
| first_indexed | 2024-03-09T22:55:22Z |
| format | Article |
| id | doaj.art-a55d2fa75e894adcb089a13e50a9f3be |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:55:22Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a55d2fa75e894adcb089a13e50a9f3be2023-11-23T18:12:08ZengMDPI AGNutrients2072-66432022-09-011418379810.3390/nu14183798Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES StudyCarla Martín-Grau0Andrés Díaz-López1Estefania Aparicio2Victoria Arija3Clinical Chemistry and Laboratory Medicine, Institut Català de la Salut, Generalitat de Catalunya, University Hospital Joan XXIII, 43005 Tarragona, SpainDepartment of Basic Medical Sciences, Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Rovira i Virgili University (URV), 43201 Reus, SpainDepartment of Basic Medical Sciences, Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Rovira i Virgili University (URV), 43201 Reus, SpainDepartment of Basic Medical Sciences, Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Rovira i Virgili University (URV), 43201 Reus, SpainMaternal short-chain fatty acids (SCFAs) play a critical role in fetal development and metabolic programming. However, an important gap in the analysis of such relationships is the lack of reference values in pregnant women. Therefore, we establish serum SCFA percentile reference ranges both early and later in pregnancy in a population from a Mediterranean region of Northern Spain. A population-based follow-up study involving 455 healthy pregnant women (mean age 30.6 ± 5.0 years) from the ECLIPSES study is conducted. Sociodemographic, obstetric, anthropometric, lifestyle, dietary variables and blood samples were collected in the first and third trimesters. Serum SCFA concentrations were measured by LC-MS/MS. The 2.5/97.5 percentiles of the reference interval for serum acetic, propionic, isobutyric, and butyric acids were 16.4/103.8 µmol/L, 2.1/5.8 µmol/L, 0.16/1.01 µmol/L and 0.32/1.67 µmol/L in the first trimester of pregnancy, respectively. In the third trimester, butyrate levels increased with most of the maternal factors and categories studied, while acetic acid and isobutyric acid decreased only in some maternal categories. Propionic acid was not affected by maternal factors. Reference ranges did not vary with maternal age, body weight, social class or diet, but decreased with smoking, high physical activity, low BMI and primiparity. This study establishes for the first-time SCFAs reference ranges in serum for women in our region in both early and late pregnancy. This information can be useful to monitor pregnancy follow-up and detect risk values.https://www.mdpi.com/2072-6643/14/18/3798short chain fatty acidreference rangespregnancyECLIPSES |
| spellingShingle | Carla Martín-Grau Andrés Díaz-López Estefania Aparicio Victoria Arija Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study Nutrients short chain fatty acid reference ranges pregnancy ECLIPSES |
| title | Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study |
| title_full | Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study |
| title_fullStr | Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study |
| title_full_unstemmed | Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study |
| title_short | Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study |
| title_sort | short chain fatty acid reference ranges in pregnant women from a mediterranean region of northern spain eclipses study |
| topic | short chain fatty acid reference ranges pregnancy ECLIPSES |
| url | https://www.mdpi.com/2072-6643/14/18/3798 |
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