Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report
The study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carci...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-07-01
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| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/411 |
| _version_ | 1797876166523092992 |
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| author | Yu. M. Bychkov A. M. Mudunov I. M. Gelfand B. G. Pkheshkhova O. D. Ryzhova А. A. Akhundov V. Z. Dobrokhotova М. N. Narimanov |
| author_facet | Yu. M. Bychkov A. M. Mudunov I. M. Gelfand B. G. Pkheshkhova O. D. Ryzhova А. A. Akhundov V. Z. Dobrokhotova М. N. Narimanov |
| author_sort | Yu. M. Bychkov |
| collection | DOAJ |
| description | The study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carcinoma with bone metastasis. After a course of radical chemoradiotherapy, the patient was found to have cancer progression. Between September 2016 and July 2017, the patient received chemotherapy with 3 lines of drugs, but with no effect. We decided to initiate treatment with PD-1 inhibitors. The patient received nivolumab 3 mg/kg every 2 weeks between July 2017 and March 2018.Results. Positron emission tomography (September 2018) demonstrated no increased uptake of [18F]-fluorodeoxyglucose in earlier identified cancer foci. Since September 2018, the patient has been in persistent remission without any therapy.Conclusion. This case report demonstrates high efficacy of PD-1 inhibitors in the treatment of disseminated recurrent nasopharyngeal squamous cell carcinoma, resistant to standard radiotherapy and chemotherapy. |
| first_indexed | 2024-04-10T01:58:53Z |
| format | Article |
| id | doaj.art-a55d5e928eac49639e0e281da4fc0868 |
| institution | Directory Open Access Journal |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| last_indexed | 2024-04-10T01:58:53Z |
| publishDate | 2019-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj.art-a55d5e928eac49639e0e281da4fc08682023-03-13T08:43:21ZrusABV-pressОпухоли головы и шеи2222-14682411-46342019-07-01929910410.17650/2222-1468-2019-9-2-99-104353Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case reportYu. M. Bychkov0A. M. Mudunov1I. M. Gelfand2B. G. Pkheshkhova3O. D. Ryzhova4А. A. Akhundov5V. Z. Dobrokhotova6М. N. Narimanov7ФГБУ «Российский научный центр рентгенорадиологии» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииThe study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carcinoma with bone metastasis. After a course of radical chemoradiotherapy, the patient was found to have cancer progression. Between September 2016 and July 2017, the patient received chemotherapy with 3 lines of drugs, but with no effect. We decided to initiate treatment with PD-1 inhibitors. The patient received nivolumab 3 mg/kg every 2 weeks between July 2017 and March 2018.Results. Positron emission tomography (September 2018) demonstrated no increased uptake of [18F]-fluorodeoxyglucose in earlier identified cancer foci. Since September 2018, the patient has been in persistent remission without any therapy.Conclusion. This case report demonstrates high efficacy of PD-1 inhibitors in the treatment of disseminated recurrent nasopharyngeal squamous cell carcinoma, resistant to standard radiotherapy and chemotherapy.https://ogsh.abvpress.ru/jour/article/view/411рак носоглоткиметастазыхимиотерапияниволумаб |
| spellingShingle | Yu. M. Bychkov A. M. Mudunov I. M. Gelfand B. G. Pkheshkhova O. D. Ryzhova А. A. Akhundov V. Z. Dobrokhotova М. N. Narimanov Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report Опухоли головы и шеи рак носоглотки метастазы химиотерапия ниволумаб |
| title | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_full | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_fullStr | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_full_unstemmed | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_short | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_sort | successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab a case report |
| topic | рак носоглотки метастазы химиотерапия ниволумаб |
| url | https://ogsh.abvpress.ru/jour/article/view/411 |
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