Anti-Cancer Effects of 3, 3’-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic Ca2+ and p38 MAPK

Anti-Cancer Effects of 3, 3’-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic Ca2+ and p38 MAPK

Purpose: 3,3′-Diindolylmethane (DIM), derived from indole-3-carbinol (I3C) in the Brassica species of cruciferous vegetables, has anticancer effects, but its exact underlying mechanism of action is unknown. We explored the roles of cytosolic free calcium ([Ca2+]i) and p38 MAPK in the anti-cancer eff...

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Bibliographic Details
Main Authors: Yuanyue Jiang, Yanfei Fang, Yang Ye, Xinming Xu, Bingfang Wang, Jie Gu, Michael Aschner, Jian Chen, Rongzhu Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
3,3′-diindolylmethane
cytosolic Ca2+
p38 MAPK
hepatocellular carcinoma cells
apoptosis
proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01167/full

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