Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic review
Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations in the structure, function, and appearance of skin. Strong or chronic exposure to a variety of stresses (e.g., ultraviolet radiation, xenobiotic agents, free r...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Journal of Agriculture and Food Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666154324001273 |
| _version_ | 1797261793359298560 |
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| author | Rawhat Un Nisa Anees Un Nisa Aadil Yousuf Tantray Ali Hyder Shah Arif Tasleem Jan Ali Asghar Shah Ishfaq Ahmad Wani |
| author_facet | Rawhat Un Nisa Anees Un Nisa Aadil Yousuf Tantray Ali Hyder Shah Arif Tasleem Jan Ali Asghar Shah Ishfaq Ahmad Wani |
| author_sort | Rawhat Un Nisa |
| collection | DOAJ |
| description | Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations in the structure, function, and appearance of skin. Strong or chronic exposure to a variety of stresses (e.g., ultraviolet radiation, xenobiotic agents, free radicals, and others) may contribute to premature skin aging, immune suppression, and tumorigenesis/carcinogenesis. Plant phenolics represent one of the largest classes of compounds used in dermatology and nutricosmetics to combat skin aging. They are produced via the polyketide and shikimate pathway. These increase skin cell longevity via the MPK-1/ERK or SIR-2.1/DAF-16, insulin/IGF-1 signaling (IGF) pathways, particularly through enhanced capacity to scavenge free radicals and fend off oxidative stress provided by the use of DAF-16 transcription factor; a sole ortholog of the FOXO family of transcription factors. Dietary polyphenols may exert their role in prevention of the skin aging effects through several possible mechanisms, such as ROS scavenging, reduction in melanin synthesis, UV impairment, removal of carcinogenic agents, modulation of cancer cell signaling antioxidant enzymatic activities, and induction of apoptosis as well as cell cycle arrest. Therefore, a search for prevention strategies to circumvent such unfavorable outcomes is being constantly pursued. The current article is designed to provide an overview of the existing literature related to skin aging and the ability of polyphenols to maintain skin homeostasis. In this review, we discuss recent progress in understanding the molecular basis of skin aging, with specific emphasis on some well-known and extensively studied polyphenols that have significant anti-aging influences and photoprotective effects. |
| first_indexed | 2024-04-24T23:46:52Z |
| format | Article |
| id | doaj.art-a55d9a0afba04d648aa3befb3809848e |
| institution | Directory Open Access Journal |
| issn | 2666-1543 |
| language | English |
| last_indexed | 2024-04-24T23:46:52Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Agriculture and Food Research |
| spelling | doaj.art-a55d9a0afba04d648aa3befb3809848e2024-03-15T04:44:38ZengElsevierJournal of Agriculture and Food Research2666-15432024-06-0116101090Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic reviewRawhat Un Nisa0Anees Un Nisa1Aadil Yousuf Tantray2Ali Hyder Shah3Arif Tasleem Jan4Ali Asghar Shah5Ishfaq Ahmad Wani6Department of Zoology, Govt. Degree College Kulgam, J&K, 192232, IndiaDepartment of Botany, University of Kashmir, J&K, 190006, IndiaDepartment of Botany, AAAM Degree College Bemina, Cluster University, Srinagar, 190018, IndiaDepartment of Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, J&K, 185234, IndiaDepartment of Botany, Baba Ghulam Shah Badshah University, Rajouri, J&K, 185234, India; Corresponding author.Department of Zoology, Baba Ghulam Shah Badshah University, Rajouri, J&K, 185234, India; Corresponding author.Department of Botany, Akal University, Talwandi Sabo, Bathinda, Punjab, 151302, India; Corresponding author.Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations in the structure, function, and appearance of skin. Strong or chronic exposure to a variety of stresses (e.g., ultraviolet radiation, xenobiotic agents, free radicals, and others) may contribute to premature skin aging, immune suppression, and tumorigenesis/carcinogenesis. Plant phenolics represent one of the largest classes of compounds used in dermatology and nutricosmetics to combat skin aging. They are produced via the polyketide and shikimate pathway. These increase skin cell longevity via the MPK-1/ERK or SIR-2.1/DAF-16, insulin/IGF-1 signaling (IGF) pathways, particularly through enhanced capacity to scavenge free radicals and fend off oxidative stress provided by the use of DAF-16 transcription factor; a sole ortholog of the FOXO family of transcription factors. Dietary polyphenols may exert their role in prevention of the skin aging effects through several possible mechanisms, such as ROS scavenging, reduction in melanin synthesis, UV impairment, removal of carcinogenic agents, modulation of cancer cell signaling antioxidant enzymatic activities, and induction of apoptosis as well as cell cycle arrest. Therefore, a search for prevention strategies to circumvent such unfavorable outcomes is being constantly pursued. The current article is designed to provide an overview of the existing literature related to skin aging and the ability of polyphenols to maintain skin homeostasis. In this review, we discuss recent progress in understanding the molecular basis of skin aging, with specific emphasis on some well-known and extensively studied polyphenols that have significant anti-aging influences and photoprotective effects.http://www.sciencedirect.com/science/article/pii/S2666154324001273PolyphenolsSkin agingROS scavengingApoptosisCancer cell signalingPhotoprotective effects |
| spellingShingle | Rawhat Un Nisa Anees Un Nisa Aadil Yousuf Tantray Ali Hyder Shah Arif Tasleem Jan Ali Asghar Shah Ishfaq Ahmad Wani Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic review Journal of Agriculture and Food Research Polyphenols Skin aging ROS scavenging Apoptosis Cancer cell signaling Photoprotective effects |
| title | Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic review |
| title_full | Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic review |
| title_fullStr | Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic review |
| title_full_unstemmed | Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic review |
| title_short | Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic review |
| title_sort | plant phenolics with promising therapeutic applications against skin disorders a mechanistic review |
| topic | Polyphenols Skin aging ROS scavenging Apoptosis Cancer cell signaling Photoprotective effects |
| url | http://www.sciencedirect.com/science/article/pii/S2666154324001273 |
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