A new parameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality
Background: COVID-19 (Coronavirus Disease-2019) is a pandemic disease, infecting more than 26.5 million people. Since there is no specific and effective treatment; early diagnosis and optimal isolation of the patient are of vital importance. Real-time polymerase chain reaction-based (RT-PCR) analyse...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187603412030664X |
| _version_ | 1818217157656313856 |
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| author | Istemi Serin Nagehan Didem Sari Mehmet Hilmi Dogu Sakine Damla Acikel Gulnıhal Babur Avni Ulusoy Mediha Irem Onar Emre Cem Gokce Oguz Altunok Feyza Yaylaci Mert Ayse Karakilic Muhammed Baltik Begum Gulesir |
| author_facet | Istemi Serin Nagehan Didem Sari Mehmet Hilmi Dogu Sakine Damla Acikel Gulnıhal Babur Avni Ulusoy Mediha Irem Onar Emre Cem Gokce Oguz Altunok Feyza Yaylaci Mert Ayse Karakilic Muhammed Baltik Begum Gulesir |
| author_sort | Istemi Serin |
| collection | DOAJ |
| description | Background: COVID-19 (Coronavirus Disease-2019) is a pandemic disease, infecting more than 26.5 million people. Since there is no specific and effective treatment; early diagnosis and optimal isolation of the patient are of vital importance. Real-time polymerase chain reaction-based (RT-PCR) analyses do not achieve sufficient sensitivity in the diagnosis of the disease. Methods: The data from 2217 patients diagnosed as COVID-19 between March 2020 and June 2020 and hospitalized or discharged with home isolation were retrospectively analyzed. Demographic data, comorbidities, PCR results, initial computed tomography (CT), laboratory values, Lactate Dehydrogenase (LDH)/Lymphocyte ratio, initial treatments and last status were recorded. The diagnostic sensitivity of LDH/Lymphocyte ratio, which is the main purpose of the study, was analyzed statistically. Results: In order to test the effectiveness of LDH/Lymphocyte ratio for COVID-19 for diagnostic purposes, CT results were considered as gold standard. The area under the curve (AUC) was found to be 0.706 (p < 0.001; cut-off > 0.06) (Sensitivity: 76.4, specificity: 59.60). For the evaluation of LDH/Lymphocyte ratio in terms of survival, AUC was found to be 0.749 (p < 0.001; cut-off > 0.21) (Sensitivity: 70.59, specificity: 73.88). Conclusion: Studies based on radiological findings have demonstrated that CT involvement has higher sensitivity. LDH/Lymphocyte ratio was analyzed in terms of diagnosis and mortality with using specific CT involvement as gold standard method which was found to be a more sensitive due to PCR false negativity; 0.06 and 0.21 were obtained as cut off values for diagnosis and mortality. |
| first_indexed | 2024-12-12T07:03:24Z |
| format | Article |
| id | doaj.art-a56166bed2bc45eab194c4fcd2c49812 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-12T07:03:24Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-a56166bed2bc45eab194c4fcd2c498122022-12-22T00:33:47ZengElsevierJournal of Infection and Public Health1876-03412020-11-01131116641670A new parameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortalityIstemi Serin0Nagehan Didem Sari1Mehmet Hilmi Dogu2Sakine Damla Acikel3Gulnıhal Babur4Avni Ulusoy5Mediha Irem Onar6Emre Cem Gokce7Oguz Altunok8Feyza Yaylaci Mert9Ayse Karakilic10Muhammed Baltik11Begum Gulesir12University of Health Sciences, Istanbul Training and Research Hospital, Department of Hematology, Fatih, Turkey; Corresponding author at: University of Health Sciences, Istanbul Training and Research Hospital, Department of Hematology, Org. Nafiz GURMAN Cad., 34098, Fatih, Istanbul.University of Health Sciences, Istanbul Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Hematology, Fatih, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Bagcilar Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Bagcilar Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Internal Medicine, TurkeyUniversity of Health Sciences, Istanbul Training and Research Hospital, Department of Internal Medicine, TurkeyBackground: COVID-19 (Coronavirus Disease-2019) is a pandemic disease, infecting more than 26.5 million people. Since there is no specific and effective treatment; early diagnosis and optimal isolation of the patient are of vital importance. Real-time polymerase chain reaction-based (RT-PCR) analyses do not achieve sufficient sensitivity in the diagnosis of the disease. Methods: The data from 2217 patients diagnosed as COVID-19 between March 2020 and June 2020 and hospitalized or discharged with home isolation were retrospectively analyzed. Demographic data, comorbidities, PCR results, initial computed tomography (CT), laboratory values, Lactate Dehydrogenase (LDH)/Lymphocyte ratio, initial treatments and last status were recorded. The diagnostic sensitivity of LDH/Lymphocyte ratio, which is the main purpose of the study, was analyzed statistically. Results: In order to test the effectiveness of LDH/Lymphocyte ratio for COVID-19 for diagnostic purposes, CT results were considered as gold standard. The area under the curve (AUC) was found to be 0.706 (p < 0.001; cut-off > 0.06) (Sensitivity: 76.4, specificity: 59.60). For the evaluation of LDH/Lymphocyte ratio in terms of survival, AUC was found to be 0.749 (p < 0.001; cut-off > 0.21) (Sensitivity: 70.59, specificity: 73.88). Conclusion: Studies based on radiological findings have demonstrated that CT involvement has higher sensitivity. LDH/Lymphocyte ratio was analyzed in terms of diagnosis and mortality with using specific CT involvement as gold standard method which was found to be a more sensitive due to PCR false negativity; 0.06 and 0.21 were obtained as cut off values for diagnosis and mortality.http://www.sciencedirect.com/science/article/pii/S187603412030664XCOVID- 19LDH/Lymphocyte ratioSensitivityDiagnosisMortality |
| spellingShingle | Istemi Serin Nagehan Didem Sari Mehmet Hilmi Dogu Sakine Damla Acikel Gulnıhal Babur Avni Ulusoy Mediha Irem Onar Emre Cem Gokce Oguz Altunok Feyza Yaylaci Mert Ayse Karakilic Muhammed Baltik Begum Gulesir A new parameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality Journal of Infection and Public Health COVID- 19 LDH/Lymphocyte ratio Sensitivity Diagnosis Mortality |
| title | A new parameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality |
| title_full | A new parameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality |
| title_fullStr | A new parameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality |
| title_full_unstemmed | A new parameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality |
| title_short | A new parameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality |
| title_sort | new parameter in covid 19 pandemic initial lactate dehydrogenase ldh lymphocyte ratio for diagnosis and mortality |
| topic | COVID- 19 LDH/Lymphocyte ratio Sensitivity Diagnosis Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S187603412030664X |
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