Association of polycystic ovary syndrome and Graves′ disease: Is autoimmunity the link between the two diseases
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy of women of child-bearing age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, to our knowledge, only a few cases indicating association between PCOS and Graves′ disease are reporte...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2012-01-01
|
| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=982;epage=986;aulast=Nisar |
| _version_ | 1811238014452498432 |
|---|---|
| author | Sobia Nisar Parvez A Shah M Shafi Kuchay Manzoor A Bhat Aafia Rashid Sanjeed Ahmed Mohd Ashraf Ganie |
| author_facet | Sobia Nisar Parvez A Shah M Shafi Kuchay Manzoor A Bhat Aafia Rashid Sanjeed Ahmed Mohd Ashraf Ganie |
| author_sort | Sobia Nisar |
| collection | DOAJ |
| description | Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy of women of child-bearing age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, to our knowledge, only a few cases indicating association between PCOS and Graves′ disease are reported. Objective: We aim to describe this first case series of six women presenting with PCOS and Graves′ disease together. Materials and Methods: Women attending the endocrinology clinic at a tertiary care centre in north India and fulfilling the AE-PCOS criteria for diagnosis of PCOS were studied using a predefined proforma for any clinical, biochemical and imaging features of Graves′ disease. Results: The series consisted of six women with a mean age of 27.5 years and menarche as 12.6 years. All women were lean with mean BMI of 22.73 kg / m 2 and three out of six had waist circumference <80 cm. The mean FG score of subjects was 16.66 and average total testosterone was 77.02 ng / dl (25.0-119.64). All the patients had suppressed TSH, the average being 0.052 μIU/ml (0.01-0.15). Thyroid gland was enlarged in all clinically and on ultrasonography and imaging with 99m Tc and/or RAIU revealed diffuse increased uptake. Conclusions: The association of a rare disorder like Graves′ disease with a relatively common disorder like PCOS is unlikely to be because of a chance alone and may point to a common aetiopathogenic linkage leaving a scope for molecular characterization. |
| first_indexed | 2024-04-12T12:34:28Z |
| format | Article |
| id | doaj.art-a561a8604db84a9c9d3b01417376c2be |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-04-12T12:34:28Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-a561a8604db84a9c9d3b01417376c2be2022-12-22T03:32:56ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002012-01-0116698298610.4103/2230-8210.103006Association of polycystic ovary syndrome and Graves′ disease: Is autoimmunity the link between the two diseasesSobia NisarParvez A ShahM Shafi KuchayManzoor A BhatAafia RashidSanjeed AhmedMohd Ashraf GanieIntroduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy of women of child-bearing age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, to our knowledge, only a few cases indicating association between PCOS and Graves′ disease are reported. Objective: We aim to describe this first case series of six women presenting with PCOS and Graves′ disease together. Materials and Methods: Women attending the endocrinology clinic at a tertiary care centre in north India and fulfilling the AE-PCOS criteria for diagnosis of PCOS were studied using a predefined proforma for any clinical, biochemical and imaging features of Graves′ disease. Results: The series consisted of six women with a mean age of 27.5 years and menarche as 12.6 years. All women were lean with mean BMI of 22.73 kg / m 2 and three out of six had waist circumference <80 cm. The mean FG score of subjects was 16.66 and average total testosterone was 77.02 ng / dl (25.0-119.64). All the patients had suppressed TSH, the average being 0.052 μIU/ml (0.01-0.15). Thyroid gland was enlarged in all clinically and on ultrasonography and imaging with 99m Tc and/or RAIU revealed diffuse increased uptake. Conclusions: The association of a rare disorder like Graves′ disease with a relatively common disorder like PCOS is unlikely to be because of a chance alone and may point to a common aetiopathogenic linkage leaving a scope for molecular characterization.http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=982;epage=986;aulast=NisarAutoimmunity and hyperandrogenismGraves′ diseasehyperthyroidismpolycystic ovary syndrome |
| spellingShingle | Sobia Nisar Parvez A Shah M Shafi Kuchay Manzoor A Bhat Aafia Rashid Sanjeed Ahmed Mohd Ashraf Ganie Association of polycystic ovary syndrome and Graves′ disease: Is autoimmunity the link between the two diseases Indian Journal of Endocrinology and Metabolism Autoimmunity and hyperandrogenism Graves′ disease hyperthyroidism polycystic ovary syndrome |
| title | Association of polycystic ovary syndrome and Graves′ disease: Is autoimmunity the link between the two diseases |
| title_full | Association of polycystic ovary syndrome and Graves′ disease: Is autoimmunity the link between the two diseases |
| title_fullStr | Association of polycystic ovary syndrome and Graves′ disease: Is autoimmunity the link between the two diseases |
| title_full_unstemmed | Association of polycystic ovary syndrome and Graves′ disease: Is autoimmunity the link between the two diseases |
| title_short | Association of polycystic ovary syndrome and Graves′ disease: Is autoimmunity the link between the two diseases |
| title_sort | association of polycystic ovary syndrome and graves disease is autoimmunity the link between the two diseases |
| topic | Autoimmunity and hyperandrogenism Graves′ disease hyperthyroidism polycystic ovary syndrome |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=982;epage=986;aulast=Nisar |
| work_keys_str_mv | AT sobianisar associationofpolycysticovarysyndromeandgravesdiseaseisautoimmunitythelinkbetweenthetwodiseases AT parvezashah associationofpolycysticovarysyndromeandgravesdiseaseisautoimmunitythelinkbetweenthetwodiseases AT mshafikuchay associationofpolycysticovarysyndromeandgravesdiseaseisautoimmunitythelinkbetweenthetwodiseases AT manzoorabhat associationofpolycysticovarysyndromeandgravesdiseaseisautoimmunitythelinkbetweenthetwodiseases AT aafiarashid associationofpolycysticovarysyndromeandgravesdiseaseisautoimmunitythelinkbetweenthetwodiseases AT sanjeedahmed associationofpolycysticovarysyndromeandgravesdiseaseisautoimmunitythelinkbetweenthetwodiseases AT mohdashrafganie associationofpolycysticovarysyndromeandgravesdiseaseisautoimmunitythelinkbetweenthetwodiseases |