Single whole genome sequencing analysis blazes the trail for precision medicine
As precision oncology evolves toward developing more targeted therapies, sequencing has moved to the forefront of treatment decision-making. Whole genome sequencing (WGS) has emerged as a technology capable of identifying candidates for rare and targeted treatments. Yet, because the tumor is constan...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Cancer Biology & Therapy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15384047.2022.2033058 |
| _version_ | 1797404060699066368 |
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| author | Giulia C. Napoli Cindy H. Chau William D. Figg |
| author_facet | Giulia C. Napoli Cindy H. Chau William D. Figg |
| author_sort | Giulia C. Napoli |
| collection | DOAJ |
| description | As precision oncology evolves toward developing more targeted therapies, sequencing has moved to the forefront of treatment decision-making. Whole genome sequencing (WGS) has emerged as a technology capable of identifying candidates for rare and targeted treatments. Yet, because the tumor is constantly evolving during relapse and therapy resistance, the frequency with which WGS should be performed to identify potential new therapies for progressing patients remains unknown. A recent study in Nature Medicine by Van de Haar et al. observed a remarkably stable driver gene mutational profile among 250 biopsy pairs from 231 patients undergoing standard of care treatments during the biopsy interval. Their findings suggest that the actionable metastatic cancer genome is relatively stable over time and that a single WGS provides a complete view of the treatment opportunities available to most metastatic cancer patients. |
| first_indexed | 2024-03-09T02:47:40Z |
| format | Article |
| id | doaj.art-a561b63df72d4859a45f54d1faaada74 |
| institution | Directory Open Access Journal |
| issn | 1538-4047 1555-8576 |
| language | English |
| last_indexed | 2024-03-09T02:47:40Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj.art-a561b63df72d4859a45f54d1faaada742023-12-05T15:58:13ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762022-12-0123113413510.1080/15384047.2022.20330582033058Single whole genome sequencing analysis blazes the trail for precision medicineGiulia C. Napoli0Cindy H. Chau1William D. Figg2Center for Cancer Research, National Cancer Institute, National Institutes of HealthCenter for Cancer Research, National Cancer Institute, National Institutes of HealthCenter for Cancer Research, National Cancer Institute, National Institutes of HealthAs precision oncology evolves toward developing more targeted therapies, sequencing has moved to the forefront of treatment decision-making. Whole genome sequencing (WGS) has emerged as a technology capable of identifying candidates for rare and targeted treatments. Yet, because the tumor is constantly evolving during relapse and therapy resistance, the frequency with which WGS should be performed to identify potential new therapies for progressing patients remains unknown. A recent study in Nature Medicine by Van de Haar et al. observed a remarkably stable driver gene mutational profile among 250 biopsy pairs from 231 patients undergoing standard of care treatments during the biopsy interval. Their findings suggest that the actionable metastatic cancer genome is relatively stable over time and that a single WGS provides a complete view of the treatment opportunities available to most metastatic cancer patients.http://dx.doi.org/10.1080/15384047.2022.2033058wgsdriver gene mutationsprecision oncologytargeted therapiesbiomarkers |
| spellingShingle | Giulia C. Napoli Cindy H. Chau William D. Figg Single whole genome sequencing analysis blazes the trail for precision medicine Cancer Biology & Therapy wgs driver gene mutations precision oncology targeted therapies biomarkers |
| title | Single whole genome sequencing analysis blazes the trail for precision medicine |
| title_full | Single whole genome sequencing analysis blazes the trail for precision medicine |
| title_fullStr | Single whole genome sequencing analysis blazes the trail for precision medicine |
| title_full_unstemmed | Single whole genome sequencing analysis blazes the trail for precision medicine |
| title_short | Single whole genome sequencing analysis blazes the trail for precision medicine |
| title_sort | single whole genome sequencing analysis blazes the trail for precision medicine |
| topic | wgs driver gene mutations precision oncology targeted therapies biomarkers |
| url | http://dx.doi.org/10.1080/15384047.2022.2033058 |
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