Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stre...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
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| Series: | Brazilian Journal of Psychiatry |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000400281&lng=en&tlng=en |
| _version_ | 1818136418306752512 |
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| author | Florencia M. Barbé-Tuana Mariana M. Parisi Bruna S. Panizzutti Gabriel R. Fries Lucas K. Grun Fátima T. Guma Flávio Kapczinski Michael Berk Clarissa S. Gama Adriane R. Rosa |
| author_facet | Florencia M. Barbé-Tuana Mariana M. Parisi Bruna S. Panizzutti Gabriel R. Fries Lucas K. Grun Fátima T. Guma Flávio Kapczinski Michael Berk Clarissa S. Gama Adriane R. Rosa |
| author_sort | Florencia M. Barbé-Tuana |
| collection | DOAJ |
| description | Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Results: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. Conclusion: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD. |
| first_indexed | 2024-12-11T09:40:05Z |
| format | Article |
| id | doaj.art-a562b40a21fe4984b2fb74b9877e647a |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-12-11T09:40:05Z |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-a562b40a21fe4984b2fb74b9877e647a2022-12-22T01:12:42ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X38428128610.1590/1516-4446-2016-1910S1516-44462016000400281Shortened telomere length in bipolar disorder: a comparison of the early and late stages of diseaseFlorencia M. Barbé-TuanaMariana M. ParisiBruna S. PanizzuttiGabriel R. FriesLucas K. GrunFátima T. GumaFlávio KapczinskiMichael BerkClarissa S. GamaAdriane R. RosaObjective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Results: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. Conclusion: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000400281&lng=en&tlng=enBipolar disordertelomerestelomere shorteningsenescencegeneticsoxidative stressinflammationmania, depressionaging |
| spellingShingle | Florencia M. Barbé-Tuana Mariana M. Parisi Bruna S. Panizzutti Gabriel R. Fries Lucas K. Grun Fátima T. Guma Flávio Kapczinski Michael Berk Clarissa S. Gama Adriane R. Rosa Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease Brazilian Journal of Psychiatry Bipolar disorder telomeres telomere shortening senescence genetics oxidative stress inflammation mania, depression aging |
| title | Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease |
| title_full | Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease |
| title_fullStr | Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease |
| title_full_unstemmed | Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease |
| title_short | Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease |
| title_sort | shortened telomere length in bipolar disorder a comparison of the early and late stages of disease |
| topic | Bipolar disorder telomeres telomere shortening senescence genetics oxidative stress inflammation mania, depression aging |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000400281&lng=en&tlng=en |
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