Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysis
Abstract Background Aseptic loosening has become the main cause of prosthetic failure in medium- to long-term follow-up. The objective of this study was to establish and validate a nomogram model for aseptic loosening after tumor prosthetic replacement around knee. Methods We collected data on patie...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-019-1423-3 |
| _version_ | 1798039005146644480 |
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| author | Hao-ran Zhang Feng Wang Xiong-gang Yang Ming-you Xu Rui-qi Qiao Ji-kai Li Yun-long Zhao Cheng-gang Pang Xiu-chun Yu Yong-cheng Hu |
| author_facet | Hao-ran Zhang Feng Wang Xiong-gang Yang Ming-you Xu Rui-qi Qiao Ji-kai Li Yun-long Zhao Cheng-gang Pang Xiu-chun Yu Yong-cheng Hu |
| author_sort | Hao-ran Zhang |
| collection | DOAJ |
| description | Abstract Background Aseptic loosening has become the main cause of prosthetic failure in medium- to long-term follow-up. The objective of this study was to establish and validate a nomogram model for aseptic loosening after tumor prosthetic replacement around knee. Methods We collected data on patients who underwent tumor prosthetic replacements. The following risk factors were analyzed: tumor site, stem length, resection length, prosthetic motion mode, sex, age, extra-cortical grafting, custom or modular, stem diameter, stem material, tumor type, activity intensity, and BMI. We used univariate and multivariate Cox regression for analysis. Finally, the significant risk factors were used to establish the nomogram model. Results The stem length, resection length, tumor site, and prosthetic motion mode showed a tendency to be related to aseptic loosening, according to the univariate analysis. Multivariate analysis showed that the tumor site, stem length, and prosthetic motion mode were independent risk factors. The internal validation indicated that the nomogram model had acceptable predictive accuracy. Conclusions A nomogram model was developed for predicting the prosthetic survival rate without aseptic loosening. Patients with distal femoral tumors and those who are applied with fixed hinge and short-stem prostheses are more likely to be exposed to aseptic loosening. |
| first_indexed | 2024-04-11T21:47:58Z |
| format | Article |
| id | doaj.art-a5631a281ee24dafba71398225cc0d80 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T21:47:58Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-a5631a281ee24dafba71398225cc0d802022-12-22T04:01:21ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2019-11-011411910.1186/s13018-019-1423-3Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysisHao-ran Zhang0Feng Wang1Xiong-gang Yang2Ming-you Xu3Rui-qi Qiao4Ji-kai Li5Yun-long Zhao6Cheng-gang Pang7Xiu-chun Yu8Yong-cheng Hu9Department of Bone Tumor, Tianjin HospitalGraduate School, Tianjin Medical UniversityGraduate School, Tianjin Medical UniversityGraduate School, Tianjin Medical UniversityGraduate School, Tianjin Medical UniversityGraduate School, Tianjin Medical UniversityGraduate School, Tianjin Medical UniversityGraduate School, Tianjin Medical UniversityDepartment of Orthopedics, General Hospital of Jinan Military Commanding RegionDepartment of Bone Tumor, Tianjin HospitalAbstract Background Aseptic loosening has become the main cause of prosthetic failure in medium- to long-term follow-up. The objective of this study was to establish and validate a nomogram model for aseptic loosening after tumor prosthetic replacement around knee. Methods We collected data on patients who underwent tumor prosthetic replacements. The following risk factors were analyzed: tumor site, stem length, resection length, prosthetic motion mode, sex, age, extra-cortical grafting, custom or modular, stem diameter, stem material, tumor type, activity intensity, and BMI. We used univariate and multivariate Cox regression for analysis. Finally, the significant risk factors were used to establish the nomogram model. Results The stem length, resection length, tumor site, and prosthetic motion mode showed a tendency to be related to aseptic loosening, according to the univariate analysis. Multivariate analysis showed that the tumor site, stem length, and prosthetic motion mode were independent risk factors. The internal validation indicated that the nomogram model had acceptable predictive accuracy. Conclusions A nomogram model was developed for predicting the prosthetic survival rate without aseptic loosening. Patients with distal femoral tumors and those who are applied with fixed hinge and short-stem prostheses are more likely to be exposed to aseptic loosening.http://link.springer.com/article/10.1186/s13018-019-1423-3Tumor prosthesisAseptic looseningRisk factorNomogram modelKnee |
| spellingShingle | Hao-ran Zhang Feng Wang Xiong-gang Yang Ming-you Xu Rui-qi Qiao Ji-kai Li Yun-long Zhao Cheng-gang Pang Xiu-chun Yu Yong-cheng Hu Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysis Journal of Orthopaedic Surgery and Research Tumor prosthesis Aseptic loosening Risk factor Nomogram model Knee |
| title | Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysis |
| title_full | Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysis |
| title_fullStr | Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysis |
| title_full_unstemmed | Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysis |
| title_short | Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysis |
| title_sort | establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee a retrospective analysis |
| topic | Tumor prosthesis Aseptic loosening Risk factor Nomogram model Knee |
| url | http://link.springer.com/article/10.1186/s13018-019-1423-3 |
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