Mouse models in colon cancer, inferences, and implications
Summary: Mouse models of colorectal cancer (CRC) have been crucial in the identification of the role of genes responsible for the full range of pathology of the human disease and have proved to be dependable for testing anti-cancer drugs. Recent research points toward the relevance of tumor, angioge...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223010350 |
| _version_ | 1797809104818798592 |
|---|---|
| author | Melanie Haas Kucherlapati |
| author_facet | Melanie Haas Kucherlapati |
| author_sort | Melanie Haas Kucherlapati |
| collection | DOAJ |
| description | Summary: Mouse models of colorectal cancer (CRC) have been crucial in the identification of the role of genes responsible for the full range of pathology of the human disease and have proved to be dependable for testing anti-cancer drugs. Recent research points toward the relevance of tumor, angiogenic, and immune microenvironments in CRC progression to late-stage disease, as well as the treatment of it. This study examines important mouse models in CRC, discussing inherent strengths and weaknesses disclosed during their construction. It endeavors to provide both a synopsis of previous work covering how investigators have defined various models and to evaluate critically how researchers are most likely to use them in the future. Accumulated evidence regarding the metastatic process and the hope of using checkpoint inhibitors and immunological inhibitor therapies points to the need for a genetically engineered mouse model that is both immunocompetent and autochthonous. |
| first_indexed | 2024-03-13T06:47:36Z |
| format | Article |
| id | doaj.art-a563c6152aae4e91aa49368710dc66e6 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-13T06:47:36Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a563c6152aae4e91aa49368710dc66e62023-06-08T04:19:45ZengElsevieriScience2589-00422023-06-01266106958Mouse models in colon cancer, inferences, and implicationsMelanie Haas Kucherlapati0Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Boston, MA, USA; Corresponding authorSummary: Mouse models of colorectal cancer (CRC) have been crucial in the identification of the role of genes responsible for the full range of pathology of the human disease and have proved to be dependable for testing anti-cancer drugs. Recent research points toward the relevance of tumor, angiogenic, and immune microenvironments in CRC progression to late-stage disease, as well as the treatment of it. This study examines important mouse models in CRC, discussing inherent strengths and weaknesses disclosed during their construction. It endeavors to provide both a synopsis of previous work covering how investigators have defined various models and to evaluate critically how researchers are most likely to use them in the future. Accumulated evidence regarding the metastatic process and the hope of using checkpoint inhibitors and immunological inhibitor therapies points to the need for a genetically engineered mouse model that is both immunocompetent and autochthonous.http://www.sciencedirect.com/science/article/pii/S2589004223010350CancerModel organism |
| spellingShingle | Melanie Haas Kucherlapati Mouse models in colon cancer, inferences, and implications iScience Cancer Model organism |
| title | Mouse models in colon cancer, inferences, and implications |
| title_full | Mouse models in colon cancer, inferences, and implications |
| title_fullStr | Mouse models in colon cancer, inferences, and implications |
| title_full_unstemmed | Mouse models in colon cancer, inferences, and implications |
| title_short | Mouse models in colon cancer, inferences, and implications |
| title_sort | mouse models in colon cancer inferences and implications |
| topic | Cancer Model organism |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223010350 |
| work_keys_str_mv | AT melaniehaaskucherlapati mousemodelsincoloncancerinferencesandimplications |