Multisystem Inflammatory Syndrome in an Adult (MIS-A) Successfully Treated with Anakinra and Glucocorticoids
During the current SARS-CoV-2 pandemic, a novel syndrome termed “multisystem inflammatory syndrome in children” (MIS-C) has emerged. MIS-C was linked to COVID-19 and shared some features with Kawasaki disease and Toxic Shock Syndrome, with a common pathogenetic substrate of hyperinflammation and cyt...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/9/7/1393 |
| _version_ | 1827601080347787264 |
|---|---|
| author | Paolo Cattaneo Alessandro Volpe Chiara Simona Cardellino Niccolò Riccardi Giulia Bertoli Tamara Ursini Arjola Ustalli Giovanni Lodi Ivan Daroui Andrea Angheben |
| author_facet | Paolo Cattaneo Alessandro Volpe Chiara Simona Cardellino Niccolò Riccardi Giulia Bertoli Tamara Ursini Arjola Ustalli Giovanni Lodi Ivan Daroui Andrea Angheben |
| author_sort | Paolo Cattaneo |
| collection | DOAJ |
| description | During the current SARS-CoV-2 pandemic, a novel syndrome termed “multisystem inflammatory syndrome in children” (MIS-C) has emerged. MIS-C was linked to COVID-19 and shared some features with Kawasaki disease and Toxic Shock Syndrome, with a common pathogenetic substrate of hyperinflammation and cytokine storm. Lately, MIS was also described in adults (≥21 years of age) and named “MIS-A”. There is no consensus about the treatment of MIS-A; successful use of glucocorticoids and immunoglobulins has been reported in case series, but more solid evidence is lacking. Furthermore, the role of biologic agents with proven benefits against COVID-19, MIS-C, or Kawasaki disease is still unexplored. In this report, we detail the clinical picture and the diagnostic process that led to the diagnosis of MIS-A in a 27-year-old man, focusing on its treatment with anakinra and glucocorticoids, which resulted in full recovery. To our knowledge, this is the first report of the successful use of anakinra for MIS-A, a drug that has already proven useful in the treatment of refractive cases of MIS-C. Anakinra may also play a pivotal role for the treatment of MIS-A. |
| first_indexed | 2024-03-09T04:48:10Z |
| format | Article |
| id | doaj.art-a5655f761ced42f283435822a9de531f |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T04:48:10Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-a5655f761ced42f283435822a9de531f2023-12-03T13:13:25ZengMDPI AGMicroorganisms2076-26072021-06-0197139310.3390/microorganisms9071393Multisystem Inflammatory Syndrome in an Adult (MIS-A) Successfully Treated with Anakinra and GlucocorticoidsPaolo Cattaneo0Alessandro Volpe1Chiara Simona Cardellino2Niccolò Riccardi3Giulia Bertoli4Tamara Ursini5Arjola Ustalli6Giovanni Lodi7Ivan Daroui8Andrea Angheben9Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyRheumatology Unit, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyPneumology Unit, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyIntensive Care Unit, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyIntensive Care Unit, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, ItalyDuring the current SARS-CoV-2 pandemic, a novel syndrome termed “multisystem inflammatory syndrome in children” (MIS-C) has emerged. MIS-C was linked to COVID-19 and shared some features with Kawasaki disease and Toxic Shock Syndrome, with a common pathogenetic substrate of hyperinflammation and cytokine storm. Lately, MIS was also described in adults (≥21 years of age) and named “MIS-A”. There is no consensus about the treatment of MIS-A; successful use of glucocorticoids and immunoglobulins has been reported in case series, but more solid evidence is lacking. Furthermore, the role of biologic agents with proven benefits against COVID-19, MIS-C, or Kawasaki disease is still unexplored. In this report, we detail the clinical picture and the diagnostic process that led to the diagnosis of MIS-A in a 27-year-old man, focusing on its treatment with anakinra and glucocorticoids, which resulted in full recovery. To our knowledge, this is the first report of the successful use of anakinra for MIS-A, a drug that has already proven useful in the treatment of refractive cases of MIS-C. Anakinra may also play a pivotal role for the treatment of MIS-A.https://www.mdpi.com/2076-2607/9/7/1393anakinraCOVID-19MIS-Amultisystem inflammatory syndromeSARS-CoV-2 |
| spellingShingle | Paolo Cattaneo Alessandro Volpe Chiara Simona Cardellino Niccolò Riccardi Giulia Bertoli Tamara Ursini Arjola Ustalli Giovanni Lodi Ivan Daroui Andrea Angheben Multisystem Inflammatory Syndrome in an Adult (MIS-A) Successfully Treated with Anakinra and Glucocorticoids Microorganisms anakinra COVID-19 MIS-A multisystem inflammatory syndrome SARS-CoV-2 |
| title | Multisystem Inflammatory Syndrome in an Adult (MIS-A) Successfully Treated with Anakinra and Glucocorticoids |
| title_full | Multisystem Inflammatory Syndrome in an Adult (MIS-A) Successfully Treated with Anakinra and Glucocorticoids |
| title_fullStr | Multisystem Inflammatory Syndrome in an Adult (MIS-A) Successfully Treated with Anakinra and Glucocorticoids |
| title_full_unstemmed | Multisystem Inflammatory Syndrome in an Adult (MIS-A) Successfully Treated with Anakinra and Glucocorticoids |
| title_short | Multisystem Inflammatory Syndrome in an Adult (MIS-A) Successfully Treated with Anakinra and Glucocorticoids |
| title_sort | multisystem inflammatory syndrome in an adult mis a successfully treated with anakinra and glucocorticoids |
| topic | anakinra COVID-19 MIS-A multisystem inflammatory syndrome SARS-CoV-2 |
| url | https://www.mdpi.com/2076-2607/9/7/1393 |
| work_keys_str_mv | AT paolocattaneo multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT alessandrovolpe multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT chiarasimonacardellino multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT niccoloriccardi multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT giuliabertoli multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT tamaraursini multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT arjolaustalli multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT giovannilodi multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT ivandaroui multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids AT andreaangheben multisysteminflammatorysyndromeinanadultmisasuccessfullytreatedwithanakinraandglucocorticoids |