MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension
Background. Monoamine oxidase (MAO) is involved in several biological processes associated with well-being and mental health, and alterations in its function might directly impact various mental disorders. Some mental disorders concomitantly occur in individuals with clinical characteristics, such a...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2023/8538027 |
| _version_ | 1797766869924446208 |
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| author | Gabriel Moura Alves Seixas Renata de Souza Freitas Caroline Ferreira Fratelli Calliandra Maria de Souza Silva Luciano Ramos de Lima Marina Morato Stival Silvana Schwerz Funghetto Izabel Cristina Rodrigues da Silva |
| author_facet | Gabriel Moura Alves Seixas Renata de Souza Freitas Caroline Ferreira Fratelli Calliandra Maria de Souza Silva Luciano Ramos de Lima Marina Morato Stival Silvana Schwerz Funghetto Izabel Cristina Rodrigues da Silva |
| author_sort | Gabriel Moura Alves Seixas |
| collection | DOAJ |
| description | Background. Monoamine oxidase (MAO) is involved in several biological processes associated with well-being and mental health, and alterations in its function might directly impact various mental disorders. Some mental disorders concomitantly occur in individuals with clinical characteristics, such as substance abuse and diabetes. Objective. To analyze the functional MAOA uVNTR polymorphism genotype frequency in an older adult population with diabetes mellitus/arterial hypertension and associate this frequency with clinical characteristics impacting daily life. Methodology. Older adults diagnosed with diabetes mellitus, systemic arterial hypertension, or both (DM/SAH) were selected and had their MAOA gene genotyped for uVNTR polymorphism. The revised Beck Depression Inventory (BDI) and a questionnaire were also applied to determine their mental health and clinical characteristics. Results. The allelic variants detected among the participants were the 2R, 3R, 4R, and 3R/4R heterozygous genotypes. Genotypes solely containing the 3R allele had patients who marked yes for smoking and alcoholism, and only those with the 3R genotypes (female 3R/3R homozygote or male 3R∗ hemizygote) were significant. Although not statistically significant, only 3R and 3R/4R genotypes presented cases of severe depression per the revised BDI interpretations. Conclusion. The MAOA uVNTR polymorphism’s low-activity 3R allele presence in an older adult population diagnosed with DM/SAH may represent a risk for developing substance use (alcohol and smoking) dependence. |
| first_indexed | 2024-03-12T20:31:32Z |
| format | Article |
| id | doaj.art-a5658f3e8fb7418da9b6489da52e97b7 |
| institution | Directory Open Access Journal |
| issn | 2090-2212 |
| language | English |
| last_indexed | 2024-03-12T20:31:32Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj.art-a5658f3e8fb7418da9b6489da52e97b72023-08-02T00:00:01ZengHindawi LimitedJournal of Aging Research2090-22122023-01-01202310.1155/2023/8538027MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial HypertensionGabriel Moura Alves Seixas0Renata de Souza Freitas1Caroline Ferreira Fratelli2Calliandra Maria de Souza Silva3Luciano Ramos de Lima4Marina Morato Stival5Silvana Schwerz Funghetto6Izabel Cristina Rodrigues da Silva7Graduate Program in Health Sciences and TechnologiesUniversity Center of Brasília (UniCEUB)Graduate Program in Health Sciences and TechnologiesFaculty of CeilândiaFaculty of CeilândiaFaculty of CeilândiaFaculty of CeilândiaFaculty of CeilândiaBackground. Monoamine oxidase (MAO) is involved in several biological processes associated with well-being and mental health, and alterations in its function might directly impact various mental disorders. Some mental disorders concomitantly occur in individuals with clinical characteristics, such as substance abuse and diabetes. Objective. To analyze the functional MAOA uVNTR polymorphism genotype frequency in an older adult population with diabetes mellitus/arterial hypertension and associate this frequency with clinical characteristics impacting daily life. Methodology. Older adults diagnosed with diabetes mellitus, systemic arterial hypertension, or both (DM/SAH) were selected and had their MAOA gene genotyped for uVNTR polymorphism. The revised Beck Depression Inventory (BDI) and a questionnaire were also applied to determine their mental health and clinical characteristics. Results. The allelic variants detected among the participants were the 2R, 3R, 4R, and 3R/4R heterozygous genotypes. Genotypes solely containing the 3R allele had patients who marked yes for smoking and alcoholism, and only those with the 3R genotypes (female 3R/3R homozygote or male 3R∗ hemizygote) were significant. Although not statistically significant, only 3R and 3R/4R genotypes presented cases of severe depression per the revised BDI interpretations. Conclusion. The MAOA uVNTR polymorphism’s low-activity 3R allele presence in an older adult population diagnosed with DM/SAH may represent a risk for developing substance use (alcohol and smoking) dependence.http://dx.doi.org/10.1155/2023/8538027 |
| spellingShingle | Gabriel Moura Alves Seixas Renata de Souza Freitas Caroline Ferreira Fratelli Calliandra Maria de Souza Silva Luciano Ramos de Lima Marina Morato Stival Silvana Schwerz Funghetto Izabel Cristina Rodrigues da Silva MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension Journal of Aging Research |
| title | MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension |
| title_full | MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension |
| title_fullStr | MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension |
| title_full_unstemmed | MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension |
| title_short | MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension |
| title_sort | maoa uvntr polymorphism influence on older adults diagnosed with diabetes mellitus systemic arterial hypertension |
| url | http://dx.doi.org/10.1155/2023/8538027 |
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