Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness
ABSTRACT: Objectives: To evaluate class suspension and mass vaccination implemented among Taipei schoolchildren during the 2009 influenza pandemic and investigate factors affecting antibody responses. Methods: We conducted 2 cohort studies on: (1) 972 schoolchildren from November 2009–March 2010 to...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222001163 |
| _version_ | 1818205178935902208 |
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| author | Pui-I Ho Wei Liu Tiger Zheng-Rong Li Ta-Chien Chan Chia-Chi Ku Yu-Hui Lien Yea-Huei Daphne Shen Juine-Ruey Chen Muh-Yong Yen Yu-Kang Tu Wan-Yu Lin Richard Compans Ping-Ing Lee Chwan-Chuen King |
| author_facet | Pui-I Ho Wei Liu Tiger Zheng-Rong Li Ta-Chien Chan Chia-Chi Ku Yu-Hui Lien Yea-Huei Daphne Shen Juine-Ruey Chen Muh-Yong Yen Yu-Kang Tu Wan-Yu Lin Richard Compans Ping-Ing Lee Chwan-Chuen King |
| author_sort | Pui-I Ho |
| collection | DOAJ |
| description | ABSTRACT: Objectives: To evaluate class suspension and mass vaccination implemented among Taipei schoolchildren during the 2009 influenza pandemic and investigate factors affecting antibody responses. Methods: We conducted 2 cohort studies on: (1) 972 schoolchildren from November 2009–March 2010 to evaluate pandemic policies and (2) 935 schoolchildren from November 2011–March 2012 to verify factors in antibody waning. Anti-influenza H1N1pdm09 hemagglutination inhibition antibodies (HI-Ab) were measured from serum samples collected before vaccination, and at 1 and 4 months after vaccination. Factors affecting HI-Ab responses were investigated through logistic regression and generalized estimating equation. Results: Seroprevalence of H1N1pdm09 before vaccination was significantly higher among schoolchildren who experienced class suspensions than those who did not (59.6% vs 47.5%, p<0.05). Participating in after-school activities (adjusted odds ratio [aOR]=2.47, p=0.047) and having ≥3 hours per week of exercise (aOR=2.86, p=0.019) were significantly correlated with H1N1pdm09 infection. Two doses of the H1N1pdm09 vaccine demonstrated significantly better antibody persistence than 1 dose (HI-Ab geometric mean titer: 132.5 vs 88.6, p=0.047). Vaccine effectiveness after controlling for preexisting immunity was 86% (32%-97%). Exercise ≥3 hours per week and preexisting immunity were significantly associated with antibody waning/maintenance. Conclusions: This study is the first to show that exercise and preexisting immunity may affect antibody waning. Further investigation is needed to identify immune correlates of protection. |
| first_indexed | 2024-12-12T03:53:01Z |
| format | Article |
| id | doaj.art-a565c1d533084955b2ba2edd38d6384b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T03:53:01Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-a565c1d533084955b2ba2edd38d6384b2022-12-22T00:39:20ZengElsevierInternational Journal of Infectious Diseases1201-97122022-08-01121226237Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic PreparednessPui-I Ho0Wei Liu1Tiger Zheng-Rong Li2Ta-Chien Chan3Chia-Chi Ku4Yu-Hui Lien5Yea-Huei Daphne Shen6Juine-Ruey Chen7Muh-Yong Yen8Yu-Kang Tu9Wan-Yu Lin10Richard Compans11Ping-Ing Lee12Chwan-Chuen King13Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, TaiwanResearch Center for Humanities & Social Sciences, Academia Sinica, Taipei, TaiwanInstitute of Immunology, College of Medicine, NTU, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, TaiwanDepartment of Infection, Yuan's General Hospital, Kaohsiung City, Taiwan; StatPlus, Inc., Taipei, TaiwanRuenHuei Biopharmaceuticals, Inc., Taipei, TaiwanTaipei City Hospital, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, TaiwanDepartment of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America (U.S.A.)Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author at: Dept. of Pediatrics, NTU Children Hospital, No. 8 Chung-Shan S. Road, Taipei 100226, Taiwan.Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, Taiwan; Corresponding author at: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei 100025, Taiwan.ABSTRACT: Objectives: To evaluate class suspension and mass vaccination implemented among Taipei schoolchildren during the 2009 influenza pandemic and investigate factors affecting antibody responses. Methods: We conducted 2 cohort studies on: (1) 972 schoolchildren from November 2009–March 2010 to evaluate pandemic policies and (2) 935 schoolchildren from November 2011–March 2012 to verify factors in antibody waning. Anti-influenza H1N1pdm09 hemagglutination inhibition antibodies (HI-Ab) were measured from serum samples collected before vaccination, and at 1 and 4 months after vaccination. Factors affecting HI-Ab responses were investigated through logistic regression and generalized estimating equation. Results: Seroprevalence of H1N1pdm09 before vaccination was significantly higher among schoolchildren who experienced class suspensions than those who did not (59.6% vs 47.5%, p<0.05). Participating in after-school activities (adjusted odds ratio [aOR]=2.47, p=0.047) and having ≥3 hours per week of exercise (aOR=2.86, p=0.019) were significantly correlated with H1N1pdm09 infection. Two doses of the H1N1pdm09 vaccine demonstrated significantly better antibody persistence than 1 dose (HI-Ab geometric mean titer: 132.5 vs 88.6, p=0.047). Vaccine effectiveness after controlling for preexisting immunity was 86% (32%-97%). Exercise ≥3 hours per week and preexisting immunity were significantly associated with antibody waning/maintenance. Conclusions: This study is the first to show that exercise and preexisting immunity may affect antibody waning. Further investigation is needed to identify immune correlates of protection.http://www.sciencedirect.com/science/article/pii/S1201971222001163pandemic influenzaemerging infectious diseasespublic health policyvaccinationseroepidemiologyTaiwan |
| spellingShingle | Pui-I Ho Wei Liu Tiger Zheng-Rong Li Ta-Chien Chan Chia-Chi Ku Yu-Hui Lien Yea-Huei Daphne Shen Juine-Ruey Chen Muh-Yong Yen Yu-Kang Tu Wan-Yu Lin Richard Compans Ping-Ing Lee Chwan-Chuen King Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness International Journal of Infectious Diseases pandemic influenza emerging infectious diseases public health policy vaccination seroepidemiology Taiwan |
| title | Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness |
| title_full | Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness |
| title_fullStr | Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness |
| title_full_unstemmed | Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness |
| title_short | Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness |
| title_sort | taiwan s response to influenza a seroepidemiological evaluation of policies and implications for pandemic preparedness |
| topic | pandemic influenza emerging infectious diseases public health policy vaccination seroepidemiology Taiwan |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222001163 |
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