Metabolic Syndrome in Adults With Congenital Heart Disease
BackgroundMetabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.114.001132 |
| _version_ | 1818314781723983872 |
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| author | Jason F. Deen Eric V. Krieger April E. Slee Alex Arslan David Arterburn Karen K. Stout Michael A. Portman |
| author_facet | Jason F. Deen Eric V. Krieger April E. Slee Alex Arslan David Arterburn Karen K. Stout Michael A. Portman |
| author_sort | Jason F. Deen |
| collection | DOAJ |
| description | BackgroundMetabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence of metabolic syndrome in ACHD patients is unknown. Methods and ResultsWe conducted a retrospective cohort study of ACHD patients at our center to quantify the prevalence of metabolic syndrome in an ACHD population. Using case‐control matching, we constructed a comparable control group from a population‐based sample of 150 104 adults. International Diabetes Federation criteria were used to define metabolic syndrome. We used logistic regression to compare the risk of metabolic syndrome across the resulting cohorts, which were composed of 448 ACHD patients and 448 controls matched by age and sex. Mean age of both groups was 32.4±11.3 years, and 51.3% were female. Obesity was present in 16.1% of the ACHD patients and 16.7% of the controls. Metabolic syndrome was more common in ACHD patients than in controls (15.0% versus 7.4%; odds ratio 1.82, 95% CI 1.25–2.65). ConclusionsOur data suggest that metabolic syndrome is more common among adults with congenital heart disease than in the general population. Thus, patients with congenital heart disease should be screened for metabolic syndrome and risk factors mitigated where possible to prevent atherosclerotic coronary artery disease. Preventive cardiology should be included during routine ACHD care. |
| first_indexed | 2024-12-13T08:55:06Z |
| format | Article |
| id | doaj.art-a565e60fd45e4c74adb1af082c6b8a22 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T08:55:06Z |
| publishDate | 2016-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-a565e60fd45e4c74adb1af082c6b8a222022-12-21T23:53:17ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-02-015210.1161/JAHA.114.001132Metabolic Syndrome in Adults With Congenital Heart DiseaseJason F. Deen0Eric V. Krieger1April E. Slee2Alex Arslan3David Arterburn4Karen K. Stout5Michael A. Portman6Division of Cardiology, Seattle Children's Hospital, University of Washington, Seattle, WADivision of Cardiology, Seattle Children's Hospital, University of Washington, Seattle, WAAxio Research, Seattle, WAAxio Research, Seattle, WADepartment of Medicine, Group Health Research Institute, Seattle, WADivision of Cardiology, Seattle Children's Hospital, University of Washington, Seattle, WADivision of Cardiology, Seattle Children's Hospital, University of Washington, Seattle, WABackgroundMetabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence of metabolic syndrome in ACHD patients is unknown. Methods and ResultsWe conducted a retrospective cohort study of ACHD patients at our center to quantify the prevalence of metabolic syndrome in an ACHD population. Using case‐control matching, we constructed a comparable control group from a population‐based sample of 150 104 adults. International Diabetes Federation criteria were used to define metabolic syndrome. We used logistic regression to compare the risk of metabolic syndrome across the resulting cohorts, which were composed of 448 ACHD patients and 448 controls matched by age and sex. Mean age of both groups was 32.4±11.3 years, and 51.3% were female. Obesity was present in 16.1% of the ACHD patients and 16.7% of the controls. Metabolic syndrome was more common in ACHD patients than in controls (15.0% versus 7.4%; odds ratio 1.82, 95% CI 1.25–2.65). ConclusionsOur data suggest that metabolic syndrome is more common among adults with congenital heart disease than in the general population. Thus, patients with congenital heart disease should be screened for metabolic syndrome and risk factors mitigated where possible to prevent atherosclerotic coronary artery disease. Preventive cardiology should be included during routine ACHD care.https://www.ahajournals.org/doi/10.1161/JAHA.114.001132atherosclerosiscongenital heart diseasemetabolic syndromerisk stratification |
| spellingShingle | Jason F. Deen Eric V. Krieger April E. Slee Alex Arslan David Arterburn Karen K. Stout Michael A. Portman Metabolic Syndrome in Adults With Congenital Heart Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atherosclerosis congenital heart disease metabolic syndrome risk stratification |
| title | Metabolic Syndrome in Adults With Congenital Heart Disease |
| title_full | Metabolic Syndrome in Adults With Congenital Heart Disease |
| title_fullStr | Metabolic Syndrome in Adults With Congenital Heart Disease |
| title_full_unstemmed | Metabolic Syndrome in Adults With Congenital Heart Disease |
| title_short | Metabolic Syndrome in Adults With Congenital Heart Disease |
| title_sort | metabolic syndrome in adults with congenital heart disease |
| topic | atherosclerosis congenital heart disease metabolic syndrome risk stratification |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.114.001132 |
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