The Seroprevalence of Hepatitis C Virus (HCV) in Hemodialysis Patients in Oman: A National Cross-Sectional Study
Abstract Background HCV infection in hemodialysis units is a significant cause of morbidity and mortality. The risk of HCV infection among dialysis patients is higher compared to the general population due to high potential blood exposures in hemodialysis settings. This study aims to assess the nati...
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| Format: | Article |
| Language: | English |
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Springer
2023-09-01
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| Series: | Journal of Epidemiology and Global Health |
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| Online Access: | https://doi.org/10.1007/s44197-023-00149-6 |
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| author | Intisar Al Shukri Adil Al Wahaibi Hanan Al kindi Yaqoub Al-Maimani Amal Al Maani Abdullah Alqayoudhi Mersum C. Methew Jini Pradeesh Raiya Al Abrawi Abdo Debs Nabila Mansoor Ahmed AlRahbi Wadha Al Balushi Mahmood Alharrasi Badriya Al Mamari Magda Fakhry Soliman Afraa Alsenaidi Mohammed Al Alawi Omaima Al Ismaili Seif Al-Abri Amina Al-Jardani |
| author_facet | Intisar Al Shukri Adil Al Wahaibi Hanan Al kindi Yaqoub Al-Maimani Amal Al Maani Abdullah Alqayoudhi Mersum C. Methew Jini Pradeesh Raiya Al Abrawi Abdo Debs Nabila Mansoor Ahmed AlRahbi Wadha Al Balushi Mahmood Alharrasi Badriya Al Mamari Magda Fakhry Soliman Afraa Alsenaidi Mohammed Al Alawi Omaima Al Ismaili Seif Al-Abri Amina Al-Jardani |
| author_sort | Intisar Al Shukri |
| collection | DOAJ |
| description | Abstract Background HCV infection in hemodialysis units is a significant cause of morbidity and mortality. The risk of HCV infection among dialysis patients is higher compared to the general population due to high potential blood exposures in hemodialysis settings. This study aims to assess the national HCV seroprevalence in selected dialysis units and to determine the risk factors for acquiring HCV infection. Methods This cross-sectional study was conducted from 1 January to 31 March 2021. A total of 734 patients from 11 hemodialysis centers in Oman were included. Samples were tested simultaneously for HCV antibodies and HCV RNA. HCV genotyping was determined in all viremic patients. Demographic and hemodialysis center related data were gathered and their association with the positive HCV serology were explored using univariate and multivariate logistic regression analysis. Results Out of 800 patients selected from 11 dialysis units for the study, 734 patients (91.8%) were included. The overall seroprevalence of HCV infection among hemodialysis patients was 5.6%. (41/734). HCV RNA was detected in 31.7% (13/41) of seropositive hemodialysis patients. The most common genotype was subtype 1a, followed by subtype 3. Variables associated with high HCV prevalence were family history of HCV and duration of dialysis. Conclusion The prevalence of infection within hemodialysis patients in Oman has significantly decreased but remained higher than the general population. Continuous monitoring and follow-up, including periodic serosurvey and linkage to care and treatment are recommended. Additionally, practice audits are recommended for identifying gaps and ensuring sustainability of best practices and further improvement. |
| first_indexed | 2024-03-09T06:01:33Z |
| format | Article |
| id | doaj.art-a56ae3e3ca83403dae03d1e4903ea3b9 |
| institution | Directory Open Access Journal |
| issn | 2210-6014 |
| language | English |
| last_indexed | 2024-03-09T06:01:33Z |
| publishDate | 2023-09-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Epidemiology and Global Health |
| spelling | doaj.art-a56ae3e3ca83403dae03d1e4903ea3b92023-12-03T12:09:18ZengSpringerJournal of Epidemiology and Global Health2210-60142023-09-0113477478110.1007/s44197-023-00149-6The Seroprevalence of Hepatitis C Virus (HCV) in Hemodialysis Patients in Oman: A National Cross-Sectional StudyIntisar Al Shukri0Adil Al Wahaibi1Hanan Al kindi2Yaqoub Al-Maimani3Amal Al Maani4Abdullah Alqayoudhi5Mersum C. Methew6Jini Pradeesh7Raiya Al Abrawi8Abdo Debs9Nabila Mansoor10Ahmed AlRahbi11Wadha Al Balushi12Mahmood Alharrasi13Badriya Al Mamari14Magda Fakhry Soliman15Afraa Alsenaidi16Mohammed Al Alawi17Omaima Al Ismaili18Seif Al-Abri19Amina Al-Jardani20Directorate General for Disease Surveillance and Control, Central Public Health Laboratories, Ministry of HealthDepartment of Surveillance, Directorate General for Disease Surveillance and Control, Ministry of HealthDirectorate General for Disease Surveillance and Control, Central Public Health Laboratories, Ministry of HealthBawshar Dialysis Center, Ministry of HealthDirectorate General for Disease Surveillance and Control, Ministry of HealthDepartment of Infection Prevention and Control, Directorate General for Disease Surveillance and Control, Ministry of HealthDirectorate General for Disease Surveillance and Control, Central Public Health Laboratories, Ministry of HealthDirectorate General for Disease Surveillance and Control, Central Public Health Laboratories, Ministry of HealthBawshar Dialysis Center, Ministry of HealthQuriyat Hospital, Ministry of HealthSalalah Dialysis Unit, Ministry of HealthIbra Dialysis Unit, Ministry of HealthSohar Hospital, Ministry of HealthAs Seeb Dialysis Center, Ministry of HealthShinas Renal Dialysis Unit, Ministry of HealthAl Buraymi Dialysis Unit, Ministry of HealthJalan Dialysis Unit, Ministry of HealthAl Rustaq Dialysis Unit, Ministry of HealthDepartment of Infection Prevention and Control, Directorate General for Disease Surveillance and Control, Ministry of HealthRoyal Hospital, Ministry of HealthDirectorate General for Disease Surveillance and Control, Central Public Health Laboratories, Ministry of HealthAbstract Background HCV infection in hemodialysis units is a significant cause of morbidity and mortality. The risk of HCV infection among dialysis patients is higher compared to the general population due to high potential blood exposures in hemodialysis settings. This study aims to assess the national HCV seroprevalence in selected dialysis units and to determine the risk factors for acquiring HCV infection. Methods This cross-sectional study was conducted from 1 January to 31 March 2021. A total of 734 patients from 11 hemodialysis centers in Oman were included. Samples were tested simultaneously for HCV antibodies and HCV RNA. HCV genotyping was determined in all viremic patients. Demographic and hemodialysis center related data were gathered and their association with the positive HCV serology were explored using univariate and multivariate logistic regression analysis. Results Out of 800 patients selected from 11 dialysis units for the study, 734 patients (91.8%) were included. The overall seroprevalence of HCV infection among hemodialysis patients was 5.6%. (41/734). HCV RNA was detected in 31.7% (13/41) of seropositive hemodialysis patients. The most common genotype was subtype 1a, followed by subtype 3. Variables associated with high HCV prevalence were family history of HCV and duration of dialysis. Conclusion The prevalence of infection within hemodialysis patients in Oman has significantly decreased but remained higher than the general population. Continuous monitoring and follow-up, including periodic serosurvey and linkage to care and treatment are recommended. Additionally, practice audits are recommended for identifying gaps and ensuring sustainability of best practices and further improvement.https://doi.org/10.1007/s44197-023-00149-6Hepatitis C virusSeroprevalenceDialysis unitOmanCross-sectional |
| spellingShingle | Intisar Al Shukri Adil Al Wahaibi Hanan Al kindi Yaqoub Al-Maimani Amal Al Maani Abdullah Alqayoudhi Mersum C. Methew Jini Pradeesh Raiya Al Abrawi Abdo Debs Nabila Mansoor Ahmed AlRahbi Wadha Al Balushi Mahmood Alharrasi Badriya Al Mamari Magda Fakhry Soliman Afraa Alsenaidi Mohammed Al Alawi Omaima Al Ismaili Seif Al-Abri Amina Al-Jardani The Seroprevalence of Hepatitis C Virus (HCV) in Hemodialysis Patients in Oman: A National Cross-Sectional Study Journal of Epidemiology and Global Health Hepatitis C virus Seroprevalence Dialysis unit Oman Cross-sectional |
| title | The Seroprevalence of Hepatitis C Virus (HCV) in Hemodialysis Patients in Oman: A National Cross-Sectional Study |
| title_full | The Seroprevalence of Hepatitis C Virus (HCV) in Hemodialysis Patients in Oman: A National Cross-Sectional Study |
| title_fullStr | The Seroprevalence of Hepatitis C Virus (HCV) in Hemodialysis Patients in Oman: A National Cross-Sectional Study |
| title_full_unstemmed | The Seroprevalence of Hepatitis C Virus (HCV) in Hemodialysis Patients in Oman: A National Cross-Sectional Study |
| title_short | The Seroprevalence of Hepatitis C Virus (HCV) in Hemodialysis Patients in Oman: A National Cross-Sectional Study |
| title_sort | seroprevalence of hepatitis c virus hcv in hemodialysis patients in oman a national cross sectional study |
| topic | Hepatitis C virus Seroprevalence Dialysis unit Oman Cross-sectional |
| url | https://doi.org/10.1007/s44197-023-00149-6 |
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