Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trial
Abstract Background Bipolar disorder (BD) is commonly associated with cognitive and functional impairments even during remission periods, and although a growing number of studies have demonstrated the benefits of psychotherapy as an add-on to pharmacological treatment, its effectiveness appears to b...
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| Format: | Article |
| Language: | English |
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BMC
2017-03-01
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| Series: | Trials |
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| Online Access: | http://link.springer.com/article/10.1186/s13063-017-1896-5 |
| _version_ | 1811281785781223424 |
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| author | Bernardo Carramão Gomes Cristiana Castanho Rocca Gabriel Okawa Belizario Beny Lafer |
| author_facet | Bernardo Carramão Gomes Cristiana Castanho Rocca Gabriel Okawa Belizario Beny Lafer |
| author_sort | Bernardo Carramão Gomes |
| collection | DOAJ |
| description | Abstract Background Bipolar disorder (BD) is commonly associated with cognitive and functional impairments even during remission periods, and although a growing number of studies have demonstrated the benefits of psychotherapy as an add-on to pharmacological treatment, its effectiveness appears to be less compelling in severe presentations of the disorder. New interventions have attempted to improve cognitive functioning in BD patients, but results have been mixed. Methods The study consists of a clinical trial comparing a new structured group intervention, called “Cognitive-Behavioral Rehabilitation,” with treatment as usual (TAU) for bipolar patients. The new approach is a combination of cognitive behavioral strategies and cognitive remediation exercises, consisting of 12 weekly group sessions of 90 min each. To be included in the study, patients must be diagnosed with BD type I or II, aged 18–55 years, in full or partial remission, and have an IQ of at least 80. A comprehensive neuropsychological battery, followed by mood, social functioning, and quality of life assessments will occur in three moments: pre and post intervention and 12 months later. The primary outcome of the study is to compare the time, in weeks, that the first full mood episode appears in patients who participated in either group of the study. Secondary outcome will include improvement in cognitive functions. Discussion This is the first controlled trial assessing the validity and effectiveness of the new “Cognitive-Behavioral Rehabilitation” intervention in preventing new mood episodes and improving cognitive and functional impairments. Trial registration Clinicaltrial.gov, NCT02766361 . Registered on 2 May 2016. |
| first_indexed | 2024-04-13T01:39:51Z |
| format | Article |
| id | doaj.art-a56d8326f54c41ff9196d11ce8686e91 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-04-13T01:39:51Z |
| publishDate | 2017-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-a56d8326f54c41ff9196d11ce8686e912022-12-22T03:08:12ZengBMCTrials1745-62152017-03-011811710.1186/s13063-017-1896-5Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trialBernardo Carramão Gomes0Cristiana Castanho Rocca1Gabriel Okawa Belizario2Beny Lafer3Department of Psychiatry, University of São Paulo School of MedicineDepartment of Psychiatry, University of São Paulo School of MedicineDepartment of Psychiatry, University of São Paulo School of MedicineDepartment of Psychiatry, University of São Paulo School of MedicineAbstract Background Bipolar disorder (BD) is commonly associated with cognitive and functional impairments even during remission periods, and although a growing number of studies have demonstrated the benefits of psychotherapy as an add-on to pharmacological treatment, its effectiveness appears to be less compelling in severe presentations of the disorder. New interventions have attempted to improve cognitive functioning in BD patients, but results have been mixed. Methods The study consists of a clinical trial comparing a new structured group intervention, called “Cognitive-Behavioral Rehabilitation,” with treatment as usual (TAU) for bipolar patients. The new approach is a combination of cognitive behavioral strategies and cognitive remediation exercises, consisting of 12 weekly group sessions of 90 min each. To be included in the study, patients must be diagnosed with BD type I or II, aged 18–55 years, in full or partial remission, and have an IQ of at least 80. A comprehensive neuropsychological battery, followed by mood, social functioning, and quality of life assessments will occur in three moments: pre and post intervention and 12 months later. The primary outcome of the study is to compare the time, in weeks, that the first full mood episode appears in patients who participated in either group of the study. Secondary outcome will include improvement in cognitive functions. Discussion This is the first controlled trial assessing the validity and effectiveness of the new “Cognitive-Behavioral Rehabilitation” intervention in preventing new mood episodes and improving cognitive and functional impairments. Trial registration Clinicaltrial.gov, NCT02766361 . Registered on 2 May 2016.http://link.springer.com/article/10.1186/s13063-017-1896-5Bipolar disorderPsychotherapyTreatment as usualTAUCognitive rehabilitationFunctional impairment |
| spellingShingle | Bernardo Carramão Gomes Cristiana Castanho Rocca Gabriel Okawa Belizario Beny Lafer Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trial Trials Bipolar disorder Psychotherapy Treatment as usual TAU Cognitive rehabilitation Functional impairment |
| title | Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trial |
| title_full | Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trial |
| title_fullStr | Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trial |
| title_full_unstemmed | Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trial |
| title_short | Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trial |
| title_sort | cognitive behavioral rehabilitation vs treatment as usual for bipolar patients study protocol for a randomized controlled trial |
| topic | Bipolar disorder Psychotherapy Treatment as usual TAU Cognitive rehabilitation Functional impairment |
| url | http://link.springer.com/article/10.1186/s13063-017-1896-5 |
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