Interaction between peripheral and central immune markers in clinical high risk for psychosis
Neuroinflammatory events prior to the diagnosis of schizophrenia may play a role in transition to illness. To date only one in-vivo study has investigated this association between peripheral proinflammatory cytokines and brain markers of inflammation (e.g., mitochondrial 18 kDa translocator protein,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354623000509 |
| _version_ | 1797797957539463168 |
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| author | Kankana Nisha Aji Sina Hafizi Tania Da Silva Michael Kiang Pablo M. Rusjan Cynthia Shannon Weickert Romina Mizrahi |
| author_facet | Kankana Nisha Aji Sina Hafizi Tania Da Silva Michael Kiang Pablo M. Rusjan Cynthia Shannon Weickert Romina Mizrahi |
| author_sort | Kankana Nisha Aji |
| collection | DOAJ |
| description | Neuroinflammatory events prior to the diagnosis of schizophrenia may play a role in transition to illness. To date only one in-vivo study has investigated this association between peripheral proinflammatory cytokines and brain markers of inflammation (e.g., mitochondrial 18 kDa translocator protein, TSPO) in schizophrenia, but none in its putative prodrome.In this study, we primarily aimed to (Barron et al., 2017) test study group (clinical high-risk (CHR) and healthy controls) differences in peripheral inflammatory markers and test for any associations with symptom measures, (Hafizi et al., 2017a) investigate the interaction between brain TSPO levels (dorsolateral prefrontal cortex (DLPFC) and hippocampus) and peripheral inflammatory clusters (entire cohort and (CHR) group independently) within a relatively large group of individuals at CHR for psychosis (N = 38) and healthy controls (N = 20). Participants underwent structural brain magnetic resonance imaging (MRI) and TSPO [18F]FEPPA positron emission tomography (PET) scans. Serum samples were assessed for peripheral inflammatory markers (i.e., CRP and interleukins). For exploratory analysis, we aimed to examine cluster differences for symptom measures and identify independent peripheral predictors of brain TSPO expression.Here, we report increased IL-8 levels that are positively correlated with prodromal general symptom severity and showed trend-level association with apathy in CHR. We identified distinct inflammatory clusters characterized by inflammatory markers (IL-1 β, IL-2, IFN-γ) that were comparable between entire cohort and CHR. TSPO levels did not differ between inflammatory clusters (entire cohort or CHR). Finally, we show that CRP, IL-1 β, TNF-α, and IFN-γ levels were the independent peripheral predictors of brain TSPO expression.Thus, alterations in brain TSPO expression in response to inflammatory processes are not evident in CHR. Taken together, clustering by inflammatory status is a promising strategy to characterize the interaction between brain TSPO and peripheral markers of inflammation. |
| first_indexed | 2024-03-13T03:57:11Z |
| format | Article |
| id | doaj.art-a56e0dc9ca4b4c229502e72ad0287e10 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-03-13T03:57:11Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-a56e0dc9ca4b4c229502e72ad0287e102023-06-22T05:05:24ZengElsevierBrain, Behavior, & Immunity - Health2666-35462023-07-0130100636Interaction between peripheral and central immune markers in clinical high risk for psychosisKankana Nisha Aji0Sina Hafizi1Tania Da Silva2Michael Kiang3Pablo M. Rusjan4Cynthia Shannon Weickert5Romina Mizrahi6Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Douglas Research Centre, Clinical and Translational Sciences Lab, Montreal, Quebec, CanadaResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, CanadaResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Douglas Research Centre, Clinical and Translational Sciences Lab, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, CanadaDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USAResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Douglas Research Centre, Clinical and Translational Sciences Lab, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Corresponding author. Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.Neuroinflammatory events prior to the diagnosis of schizophrenia may play a role in transition to illness. To date only one in-vivo study has investigated this association between peripheral proinflammatory cytokines and brain markers of inflammation (e.g., mitochondrial 18 kDa translocator protein, TSPO) in schizophrenia, but none in its putative prodrome.In this study, we primarily aimed to (Barron et al., 2017) test study group (clinical high-risk (CHR) and healthy controls) differences in peripheral inflammatory markers and test for any associations with symptom measures, (Hafizi et al., 2017a) investigate the interaction between brain TSPO levels (dorsolateral prefrontal cortex (DLPFC) and hippocampus) and peripheral inflammatory clusters (entire cohort and (CHR) group independently) within a relatively large group of individuals at CHR for psychosis (N = 38) and healthy controls (N = 20). Participants underwent structural brain magnetic resonance imaging (MRI) and TSPO [18F]FEPPA positron emission tomography (PET) scans. Serum samples were assessed for peripheral inflammatory markers (i.e., CRP and interleukins). For exploratory analysis, we aimed to examine cluster differences for symptom measures and identify independent peripheral predictors of brain TSPO expression.Here, we report increased IL-8 levels that are positively correlated with prodromal general symptom severity and showed trend-level association with apathy in CHR. We identified distinct inflammatory clusters characterized by inflammatory markers (IL-1 β, IL-2, IFN-γ) that were comparable between entire cohort and CHR. TSPO levels did not differ between inflammatory clusters (entire cohort or CHR). Finally, we show that CRP, IL-1 β, TNF-α, and IFN-γ levels were the independent peripheral predictors of brain TSPO expression.Thus, alterations in brain TSPO expression in response to inflammatory processes are not evident in CHR. Taken together, clustering by inflammatory status is a promising strategy to characterize the interaction between brain TSPO and peripheral markers of inflammation.http://www.sciencedirect.com/science/article/pii/S2666354623000509Clinical high-riskPeripheral inflammationNeuroinflammationMRIPETTSPO |
| spellingShingle | Kankana Nisha Aji Sina Hafizi Tania Da Silva Michael Kiang Pablo M. Rusjan Cynthia Shannon Weickert Romina Mizrahi Interaction between peripheral and central immune markers in clinical high risk for psychosis Brain, Behavior, & Immunity - Health Clinical high-risk Peripheral inflammation Neuroinflammation MRI PET TSPO |
| title | Interaction between peripheral and central immune markers in clinical high risk for psychosis |
| title_full | Interaction between peripheral and central immune markers in clinical high risk for psychosis |
| title_fullStr | Interaction between peripheral and central immune markers in clinical high risk for psychosis |
| title_full_unstemmed | Interaction between peripheral and central immune markers in clinical high risk for psychosis |
| title_short | Interaction between peripheral and central immune markers in clinical high risk for psychosis |
| title_sort | interaction between peripheral and central immune markers in clinical high risk for psychosis |
| topic | Clinical high-risk Peripheral inflammation Neuroinflammation MRI PET TSPO |
| url | http://www.sciencedirect.com/science/article/pii/S2666354623000509 |
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