Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis
BackgroundTo evaluate gender differences in disease activity and health status (HS) in patients with radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS).MethodsAncillary analysis of the MIDAS study, an observational, non-interventional, cross-sectional and retrospective multic...
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| Format: | Article |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1078325/full |
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| author | Cristina Fernández-Carballido Vega Jovaní Emma Beltrán Catalán Manuel José Moreno-Ramos Jesús Sanz Sanz Adela Gallego M. Luz García Vivar José Manuel Rodríguez-Heredia Cristina Sanabra Carlos Sastré |
| author_facet | Cristina Fernández-Carballido Vega Jovaní Emma Beltrán Catalán Manuel José Moreno-Ramos Jesús Sanz Sanz Adela Gallego M. Luz García Vivar José Manuel Rodríguez-Heredia Cristina Sanabra Carlos Sastré |
| author_sort | Cristina Fernández-Carballido |
| collection | DOAJ |
| description | BackgroundTo evaluate gender differences in disease activity and health status (HS) in patients with radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS).MethodsAncillary analysis of the MIDAS study, an observational, non-interventional, cross-sectional and retrospective multicenter nationwide study to assess disease activity and its relationship with HS in clinical practice. Adult patients with AS diagnosis, fulfilling ASAS and modified New York criteria, treated for ≥3 months upon study inclusion according to clinical practice were included. The primary outcome was “disease control” assessed by the percentage of patients in remission and low disease activity (BASDAI and ASDAS-CRP scores). HS was evaluated using the ASAS health index (ASAS-HI). Patients' responses and characteristics were analyzed by gender.ResultsWe analyzed 313 patients with AS, 237 (75.7%) males and 76 (24.3%) females. A total of 202 (64.5%) patients had adequate disease control (BASDAI < 4); 69.2% of males [mean (SD) BASDAI 2.9 (2.1)] and 50.0% of females [mean (SD) BASDAI 3.8 (2.4); p = 0.01]. According to ASDAS-CRP, 57.5% of patients were adequately controlled (ASDAS-ID +ASDAS-LDA); 138 (58.2%) males and 42 (55.3%) females. The mean (SD) ASDAS-CRP was 1.9 (1.1); being 1.9 (1.0) in males and 2.0 (1.1) in females. Overall, the impact of AS on HS was low to moderate [mean (SD) ASAS-HI 5.8 (4.4)]; being 5.5 (4.4) for males and 6.8 (4.2) for females (p = 0.02).ConclusionThis study showed a higher proportion of females with AS and active disease using the BASDAI definition. When using the ASDAS-CRP definition these differences by gender were less pronounced. The impact of disease activity on HS appears to be higher in females than males. |
| first_indexed | 2024-04-13T03:42:48Z |
| format | Article |
| id | doaj.art-a56e69b0dc284405a1e2067791965794 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T03:42:48Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-a56e69b0dc284405a1e20677919657942022-12-22T03:04:06ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-12-01910.3389/fmed.2022.10783251078325Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysisCristina Fernández-Carballido0Vega Jovaní1Emma Beltrán Catalán2Manuel José Moreno-Ramos3Jesús Sanz Sanz4Adela Gallego5M. Luz García Vivar6José Manuel Rodríguez-Heredia7Cristina Sanabra8Carlos Sastré9Department of Rheumatology, Hospital Universitario San Juan de Alicante, Alicante, SpainDepartment of Rheumatology, Hospital General Universitario Dr. Balmis, Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, SpainDepartment of Rheumatology, Hospital del Mar, Barcelona, SpainDepartment of Rheumatology, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, SpainDepartment of Rheumatology, Hospital Universitario Puerta de Hierro, Madrid, SpainDepartment of Rheumatology, Complejo Hospitalario Universitario de Badajoz, Badajoz, SpainDepartment of Rheumatology, Hospital Universitario Basurto, Bilbao, SpainDepartment of Rheumatology, Hospital Universitario de Getafe, Madrid, SpainNovartis Farmacéutica, Barcelona, SpainNovartis Farmacéutica, Barcelona, SpainBackgroundTo evaluate gender differences in disease activity and health status (HS) in patients with radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS).MethodsAncillary analysis of the MIDAS study, an observational, non-interventional, cross-sectional and retrospective multicenter nationwide study to assess disease activity and its relationship with HS in clinical practice. Adult patients with AS diagnosis, fulfilling ASAS and modified New York criteria, treated for ≥3 months upon study inclusion according to clinical practice were included. The primary outcome was “disease control” assessed by the percentage of patients in remission and low disease activity (BASDAI and ASDAS-CRP scores). HS was evaluated using the ASAS health index (ASAS-HI). Patients' responses and characteristics were analyzed by gender.ResultsWe analyzed 313 patients with AS, 237 (75.7%) males and 76 (24.3%) females. A total of 202 (64.5%) patients had adequate disease control (BASDAI < 4); 69.2% of males [mean (SD) BASDAI 2.9 (2.1)] and 50.0% of females [mean (SD) BASDAI 3.8 (2.4); p = 0.01]. According to ASDAS-CRP, 57.5% of patients were adequately controlled (ASDAS-ID +ASDAS-LDA); 138 (58.2%) males and 42 (55.3%) females. The mean (SD) ASDAS-CRP was 1.9 (1.1); being 1.9 (1.0) in males and 2.0 (1.1) in females. Overall, the impact of AS on HS was low to moderate [mean (SD) ASAS-HI 5.8 (4.4)]; being 5.5 (4.4) for males and 6.8 (4.2) for females (p = 0.02).ConclusionThis study showed a higher proportion of females with AS and active disease using the BASDAI definition. When using the ASDAS-CRP definition these differences by gender were less pronounced. The impact of disease activity on HS appears to be higher in females than males.https://www.frontiersin.org/articles/10.3389/fmed.2022.1078325/fullgenderdisease activityankylosing spondylitis (AS)health statusBASDAIASDAS-CRP |
| spellingShingle | Cristina Fernández-Carballido Vega Jovaní Emma Beltrán Catalán Manuel José Moreno-Ramos Jesús Sanz Sanz Adela Gallego M. Luz García Vivar José Manuel Rodríguez-Heredia Cristina Sanabra Carlos Sastré Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis Frontiers in Medicine gender disease activity ankylosing spondylitis (AS) health status BASDAI ASDAS-CRP |
| title | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
| title_full | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
| title_fullStr | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
| title_full_unstemmed | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
| title_short | Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis |
| title_sort | disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis a real world nationwide analysis |
| topic | gender disease activity ankylosing spondylitis (AS) health status BASDAI ASDAS-CRP |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1078325/full |
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