Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment
Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading me...
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MDPI AG
2021-05-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/22/10/5278 |
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author | Andrew E. Massey Shabnam Malik Mohammad Sikander Kyle A. Doxtater Manish K. Tripathi Sheema Khan Murali M. Yallapu Meena Jaggi Subhash C. Chauhan Bilal B. Hafeez |
author_facet | Andrew E. Massey Shabnam Malik Mohammad Sikander Kyle A. Doxtater Manish K. Tripathi Sheema Khan Murali M. Yallapu Meena Jaggi Subhash C. Chauhan Bilal B. Hafeez |
author_sort | Andrew E. Massey |
collection | DOAJ |
description | Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications. |
first_indexed | 2024-03-10T11:20:14Z |
format | Article |
id | doaj.art-a570d3d950d64a4d85fd5b2692d28707 |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T11:20:14Z |
publishDate | 2021-05-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-a570d3d950d64a4d85fd5b2692d287072023-11-21T20:08:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012210527810.3390/ijms22105278Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer TreatmentAndrew E. Massey0Shabnam Malik1Mohammad Sikander2Kyle A. Doxtater3Manish K. Tripathi4Sheema Khan5Murali M. Yallapu6Meena Jaggi7Subhash C. Chauhan8Bilal B. Hafeez9National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USAExosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications.https://www.mdpi.com/1422-0067/22/10/5278exosometumor microenvironmentmiRNAslncRNAs |
spellingShingle | Andrew E. Massey Shabnam Malik Mohammad Sikander Kyle A. Doxtater Manish K. Tripathi Sheema Khan Murali M. Yallapu Meena Jaggi Subhash C. Chauhan Bilal B. Hafeez Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment International Journal of Molecular Sciences exosome tumor microenvironment miRNAs lncRNAs |
title | Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment |
title_full | Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment |
title_fullStr | Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment |
title_full_unstemmed | Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment |
title_short | Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment |
title_sort | clinical implications of exosomes targeted drug delivery for cancer treatment |
topic | exosome tumor microenvironment miRNAs lncRNAs |
url | https://www.mdpi.com/1422-0067/22/10/5278 |
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