Dynamic RNA 3′ Uridylation and Guanylation during Mitosis
Summary: Successful cell division involves highly regulated transcriptional and post-transcriptional control. The RNA poly(A) tail represents an important layer of RNA post-transcriptional regulation. Previous TAIL-seq analysis of S phase and M phase poly(A) tail information showed that only a small...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-08-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220305927 |
| _version_ | 1818720366402469888 |
|---|---|
| author | Yusheng Liu Hu Nie Falong Lu |
| author_facet | Yusheng Liu Hu Nie Falong Lu |
| author_sort | Yusheng Liu |
| collection | DOAJ |
| description | Summary: Successful cell division involves highly regulated transcriptional and post-transcriptional control. The RNA poly(A) tail represents an important layer of RNA post-transcriptional regulation. Previous TAIL-seq analysis of S phase and M phase poly(A) tail information showed that only a small number of genes showed more than 2-fold change in their poly(A) tail length between the two cell cycle stages. In addition, the changes in poly(A) tail length between these two stages showed minimal impact on the translation of the genes as long as the poly(A) tails were longer than 20 nt. Therefore, the significance of poly(A) tail dynamics during the cell cycle remains largely unknown. Here, by re-analyzing the S phase and M phase TAIL-seq data, we uncovered an interesting global dynamics of RNA poly(A) tails in terms of their terminal modifications, implying global RNA regulation between mitotic cell cycles through poly(A) tail terminal modifications. |
| first_indexed | 2024-12-17T20:21:42Z |
| format | Article |
| id | doaj.art-a570e0aaf9f24ea0b44a8dcf751945bd |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-17T20:21:42Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a570e0aaf9f24ea0b44a8dcf751945bd2022-12-21T21:33:55ZengElsevieriScience2589-00422020-08-01238101402Dynamic RNA 3′ Uridylation and Guanylation during MitosisYusheng Liu0Hu Nie1Falong Lu2State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding authorSummary: Successful cell division involves highly regulated transcriptional and post-transcriptional control. The RNA poly(A) tail represents an important layer of RNA post-transcriptional regulation. Previous TAIL-seq analysis of S phase and M phase poly(A) tail information showed that only a small number of genes showed more than 2-fold change in their poly(A) tail length between the two cell cycle stages. In addition, the changes in poly(A) tail length between these two stages showed minimal impact on the translation of the genes as long as the poly(A) tails were longer than 20 nt. Therefore, the significance of poly(A) tail dynamics during the cell cycle remains largely unknown. Here, by re-analyzing the S phase and M phase TAIL-seq data, we uncovered an interesting global dynamics of RNA poly(A) tails in terms of their terminal modifications, implying global RNA regulation between mitotic cell cycles through poly(A) tail terminal modifications.http://www.sciencedirect.com/science/article/pii/S2589004220305927Molecular BiologyTranscriptomics |
| spellingShingle | Yusheng Liu Hu Nie Falong Lu Dynamic RNA 3′ Uridylation and Guanylation during Mitosis iScience Molecular Biology Transcriptomics |
| title | Dynamic RNA 3′ Uridylation and Guanylation during Mitosis |
| title_full | Dynamic RNA 3′ Uridylation and Guanylation during Mitosis |
| title_fullStr | Dynamic RNA 3′ Uridylation and Guanylation during Mitosis |
| title_full_unstemmed | Dynamic RNA 3′ Uridylation and Guanylation during Mitosis |
| title_short | Dynamic RNA 3′ Uridylation and Guanylation during Mitosis |
| title_sort | dynamic rna 3 uridylation and guanylation during mitosis |
| topic | Molecular Biology Transcriptomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220305927 |
| work_keys_str_mv | AT yushengliu dynamicrna3uridylationandguanylationduringmitosis AT hunie dynamicrna3uridylationandguanylationduringmitosis AT falonglu dynamicrna3uridylationandguanylationduringmitosis |