Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable

Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable

Computational models of cardiac electrophysiology provided insights into arrhythmogenesis and paved the way towards tailored therapies in the last years. To fully leverage in-silico models in future research, these models need to be adapted to reflect pathologies, genetic alterations, or pharmacolog...

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Bibliographic Details
Main Authors: Axel eLoewe, Mathias eWilhelms, Jochen eSchmid, Mathias J. Krause, Fathima eFischer, Dierk eThomas, Eberhard P. Scholz, Olaf eDössel, Gunnar eSeemann
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Electrophysiology
patch clamp
parameter estimation
ionic currents
Particle Swarm Optimization
hybrid optimzation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00209/full

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