Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.

Herpesviruses are large DNA viruses which depend on many nuclear functions, and therefore on host transport factors to ensure specific nuclear import of viral and host components. While some import cargoes bind directly to certain transport factors, most recruit importin β1 via importin α. We identi...

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Bibliographic Details
Main Authors: Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006823

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