Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells

Reticulocalbin‐1 (RCN1) is expressed aberrantly and at a high level in various tumors, including acute myeloid leukemia (AML), yet its impact on AML remains unclear. In this study, we demonstrate that RCN1 knockdown significantly suppresses the viability of bone marrow mononuclear cells (BMMNCs) fro...

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Bibliographic Details
Main Authors: Sisi Deng, Yuming Pan, Na An, Fengyi Chen, Huan Chen, Heng Wang, Xiaojing Xu, Rui Liu, Linlin Yang, Xiaomei Wang, Xin Du, Qiaoxia Zhang
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Molecular Oncology
Subjects:
AML
caspase‐1
GSDMD
IFN‐1
pyroptosis
RCN1
Online Access:https://doi.org/10.1002/1878-0261.13521

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