Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the Literature
Background: Data about liver transplantation for mixed tumors from hepatocellular carcinoma to cholangiocarcinoma are limited. Furthermore, the diagnosis of intrahepatic cholangiocarcinoma or combined tumors in a cirrhotic liver is considered a contraindication for transplantation. Our aim was to ev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/14/3609 |
| _version_ | 1797589913421479936 |
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| author | Laura Schwenk Oliver Rohland Aladdin Ali-Deeb Felix Dondorf Utz Settmacher Falk Rauchfuß |
| author_facet | Laura Schwenk Oliver Rohland Aladdin Ali-Deeb Felix Dondorf Utz Settmacher Falk Rauchfuß |
| author_sort | Laura Schwenk |
| collection | DOAJ |
| description | Background: Data about liver transplantation for mixed tumors from hepatocellular carcinoma to cholangiocarcinoma are limited. Furthermore, the diagnosis of intrahepatic cholangiocarcinoma or combined tumors in a cirrhotic liver is considered a contraindication for transplantation. Our aim was to evaluate the long-term outcomes of patients with incidental cholangiocarcinoma or combined tumors after liver transplantation. Methods: In our descriptive analysis, data were evaluated from all patients since 2010 who received a liver transplant due to an assumed hepatocellular carcinoma at Jena University Hospital. Survival rates were determined using the Kaplan–Meier method. Results: Between January 2010 and December 2022, an incidental intrahepatic cholangiocarcinoma was found in eight patients post-transplant. Four combined hepatocellular and cholangiocarcinoma and four sole intrahepatic cholangiocarcinomas were found. A recurrence through distant metastases from combined hepatocellular- and cholangiocarcinoma was found in one patient at one year after transplantation. Another patient developed a pulmonary primary tumor independently one year post-transplant. The recurrence rate was at 14.3%. While two patients died, the 1- and 5-year overall survival rates post-transplant were 87.5% and 75%, respectively. Conclusion: Patients with intrahepatic cholangiocarcinoma or combined hepatocellular- and cholangiocarcinoma could profit from liver transplantation. |
| first_indexed | 2024-03-11T01:13:49Z |
| format | Article |
| id | doaj.art-a57732d7360b4d64891b715c4149f491 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:13:49Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a57732d7360b4d64891b715c4149f4912023-11-18T18:41:31ZengMDPI AGCancers2072-66942023-07-011514360910.3390/cancers15143609Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the LiteratureLaura Schwenk0Oliver Rohland1Aladdin Ali-Deeb2Felix Dondorf3Utz Settmacher4Falk Rauchfuß5Department of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07740 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07740 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07740 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07740 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07740 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07740 Jena, GermanyBackground: Data about liver transplantation for mixed tumors from hepatocellular carcinoma to cholangiocarcinoma are limited. Furthermore, the diagnosis of intrahepatic cholangiocarcinoma or combined tumors in a cirrhotic liver is considered a contraindication for transplantation. Our aim was to evaluate the long-term outcomes of patients with incidental cholangiocarcinoma or combined tumors after liver transplantation. Methods: In our descriptive analysis, data were evaluated from all patients since 2010 who received a liver transplant due to an assumed hepatocellular carcinoma at Jena University Hospital. Survival rates were determined using the Kaplan–Meier method. Results: Between January 2010 and December 2022, an incidental intrahepatic cholangiocarcinoma was found in eight patients post-transplant. Four combined hepatocellular and cholangiocarcinoma and four sole intrahepatic cholangiocarcinomas were found. A recurrence through distant metastases from combined hepatocellular- and cholangiocarcinoma was found in one patient at one year after transplantation. Another patient developed a pulmonary primary tumor independently one year post-transplant. The recurrence rate was at 14.3%. While two patients died, the 1- and 5-year overall survival rates post-transplant were 87.5% and 75%, respectively. Conclusion: Patients with intrahepatic cholangiocarcinoma or combined hepatocellular- and cholangiocarcinoma could profit from liver transplantation.https://www.mdpi.com/2072-6694/15/14/3609liver transplantationintrahepatic cholangiocarcinomacombined hepatocellular cholangiocarcinomatransplant outcome |
| spellingShingle | Laura Schwenk Oliver Rohland Aladdin Ali-Deeb Felix Dondorf Utz Settmacher Falk Rauchfuß Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the Literature Cancers liver transplantation intrahepatic cholangiocarcinoma combined hepatocellular cholangiocarcinoma transplant outcome |
| title | Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the Literature |
| title_full | Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the Literature |
| title_fullStr | Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the Literature |
| title_full_unstemmed | Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the Literature |
| title_short | Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the Literature |
| title_sort | liver transplantation for incidental cholangiocarcinoma or combined hepatocellular carcinoma cholangiocarcinoma own experiences and review of the literature |
| topic | liver transplantation intrahepatic cholangiocarcinoma combined hepatocellular cholangiocarcinoma transplant outcome |
| url | https://www.mdpi.com/2072-6694/15/14/3609 |
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