T cell metabolism in graft-versus-host disease
Abstract. Graft-versus-host disease (GVHD) is a major source of morbidity and mortality following allogeneic hematopoietic stem cell transplant (allo-HSCT), one of the most effective approaches to treat hematopoietic malignancies.1 However, current prophylaxis regimens and treatments that reduce the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health
2020-01-01
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| Series: | Blood Science |
| Online Access: | http://journals.lww.com/10.1097/BS9.0000000000000035 |
| _version_ | 1818744643848765440 |
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| author | Yujing Zou Benny J. Chen |
| author_facet | Yujing Zou Benny J. Chen |
| author_sort | Yujing Zou |
| collection | DOAJ |
| description | Abstract. Graft-versus-host disease (GVHD) is a major source of morbidity and mortality following allogeneic hematopoietic stem cell transplant (allo-HSCT), one of the most effective approaches to treat hematopoietic malignancies.1 However, current prophylaxis regimens and treatments that reduce the detrimental effect of acute GVHD can be offset by increased incidence in opportunistic infections and relapse of the primary malignancy.2 In addition, the majority of the approaches that inhibit T cell responses are non-specific, resulting in the inhibition of both alloreactive T cells and protective T cells from the donor. Therefore, there is an increase in the demand to develop novel approaches that selectively target alloreactive T cells. One potential means to address this issue is to take advantage of the unique metabolic profile of activated T cells. |
| first_indexed | 2024-12-18T02:47:34Z |
| format | Article |
| id | doaj.art-a578cba0d2ea4c40b9b4304b9d80afd3 |
| institution | Directory Open Access Journal |
| issn | 2543-6368 |
| language | English |
| last_indexed | 2024-12-18T02:47:34Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Blood Science |
| spelling | doaj.art-a578cba0d2ea4c40b9b4304b9d80afd32022-12-21T21:23:32ZengWolters Kluwer HealthBlood Science2543-63682020-01-0121162110.1097/BS9.0000000000000035202001000-00004T cell metabolism in graft-versus-host diseaseYujing Zou0Benny J. Chen1Division of Hematologic Malignancies and Cellular Therapy/BMT, Duke University Medical Center, Durham, NC, USADivision of Hematologic Malignancies and Cellular Therapy/BMT, Duke University Medical Center, Durham, NC, USAAbstract. Graft-versus-host disease (GVHD) is a major source of morbidity and mortality following allogeneic hematopoietic stem cell transplant (allo-HSCT), one of the most effective approaches to treat hematopoietic malignancies.1 However, current prophylaxis regimens and treatments that reduce the detrimental effect of acute GVHD can be offset by increased incidence in opportunistic infections and relapse of the primary malignancy.2 In addition, the majority of the approaches that inhibit T cell responses are non-specific, resulting in the inhibition of both alloreactive T cells and protective T cells from the donor. Therefore, there is an increase in the demand to develop novel approaches that selectively target alloreactive T cells. One potential means to address this issue is to take advantage of the unique metabolic profile of activated T cells.http://journals.lww.com/10.1097/BS9.0000000000000035 |
| spellingShingle | Yujing Zou Benny J. Chen T cell metabolism in graft-versus-host disease Blood Science |
| title | T cell metabolism in graft-versus-host disease |
| title_full | T cell metabolism in graft-versus-host disease |
| title_fullStr | T cell metabolism in graft-versus-host disease |
| title_full_unstemmed | T cell metabolism in graft-versus-host disease |
| title_short | T cell metabolism in graft-versus-host disease |
| title_sort | t cell metabolism in graft versus host disease |
| url | http://journals.lww.com/10.1097/BS9.0000000000000035 |
| work_keys_str_mv | AT yujingzou tcellmetabolismingraftversushostdisease AT bennyjchen tcellmetabolismingraftversushostdisease |