Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease
Non-alcoholic Fatty Liver Disease (NAFLD) is a chronic liver disease that is strongly related to insulin resistance and metabolic syndrome, and it has become the most common liver disorder in developed countries. NAFLD embraces the full pathological process of three conditions: steatosis, non-alcoho...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1046497/full |
| _version_ | 1828115699403325440 |
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| author | Jincheng Wang Tao Qin Jinyu Sun Shiwu Li Lihua Cao Xiaojie Lu |
| author_facet | Jincheng Wang Tao Qin Jinyu Sun Shiwu Li Lihua Cao Xiaojie Lu |
| author_sort | Jincheng Wang |
| collection | DOAJ |
| description | Non-alcoholic Fatty Liver Disease (NAFLD) is a chronic liver disease that is strongly related to insulin resistance and metabolic syndrome, and it has become the most common liver disorder in developed countries. NAFLD embraces the full pathological process of three conditions: steatosis, non-alcoholic steatohepatitis, and finally, cirrhosis. As NAFLD progresses, symptoms will become increasingly severe as fibrosis develops. Therefore, evaluating the fibrosis stage is crucial for patients with NAFLD. A liver biopsy is currently considered the gold standard for staging fibrosis. However, due to the limitations of liver biopsy, non-invasive alternatives were extensively studied and validated in patients with NAFLD. The advantages of non-invasive methods include their high safety and convenience compared with other invasive approaches. This review introduces the non-invasive methods, summarizes their benefits and limitations, and assesses their diagnostic performance for NAFLD-induced fibrosis. |
| first_indexed | 2024-04-11T12:44:31Z |
| format | Article |
| id | doaj.art-a57966a7e6b64ff69ac75c1d9829271f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T12:44:31Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-a57966a7e6b64ff69ac75c1d9829271f2022-12-22T04:23:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-12-011310.3389/fphys.2022.10464971046497Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver diseaseJincheng Wang0Tao Qin1Jinyu Sun2Shiwu Li3Lihua Cao4Xiaojie Lu5The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaThe First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaThe First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaLiver Disease Center, Qinhuangdao Third Hospital, Qinhuangdao, ChinaLiver Disease Center, Qinhuangdao Third Hospital, Qinhuangdao, ChinaThe First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaNon-alcoholic Fatty Liver Disease (NAFLD) is a chronic liver disease that is strongly related to insulin resistance and metabolic syndrome, and it has become the most common liver disorder in developed countries. NAFLD embraces the full pathological process of three conditions: steatosis, non-alcoholic steatohepatitis, and finally, cirrhosis. As NAFLD progresses, symptoms will become increasingly severe as fibrosis develops. Therefore, evaluating the fibrosis stage is crucial for patients with NAFLD. A liver biopsy is currently considered the gold standard for staging fibrosis. However, due to the limitations of liver biopsy, non-invasive alternatives were extensively studied and validated in patients with NAFLD. The advantages of non-invasive methods include their high safety and convenience compared with other invasive approaches. This review introduces the non-invasive methods, summarizes their benefits and limitations, and assesses their diagnostic performance for NAFLD-induced fibrosis.https://www.frontiersin.org/articles/10.3389/fphys.2022.1046497/fullNAFLDnon-invasive diagnosisliver fibrosisbiomarkersprediction |
| spellingShingle | Jincheng Wang Tao Qin Jinyu Sun Shiwu Li Lihua Cao Xiaojie Lu Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease Frontiers in Physiology NAFLD non-invasive diagnosis liver fibrosis biomarkers prediction |
| title | Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease |
| title_full | Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease |
| title_fullStr | Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease |
| title_full_unstemmed | Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease |
| title_short | Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease |
| title_sort | non invasive methods to evaluate liver fibrosis in patients with non alcoholic fatty liver disease |
| topic | NAFLD non-invasive diagnosis liver fibrosis biomarkers prediction |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1046497/full |
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