Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS

Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS

Carbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use cause the reduction of its therapeutic efficacy....

Full description

Bibliographic Details
Main Authors: T. A. Rodina, E. S. Melnikov, A. V. Sokolov, A. B. Prokofiev, V. V. Arkhipov, G. V. Adamov, D. L. Pozdnyakov, Yu. V. Olefir
Format: Article
Language:Russian
Published: Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2018-02-01
Series:Регуляторные исследования и экспертиза лекарственных средств
Subjects:
carbamazepine
carbamazepine-10,11-epoxyde
therapeutic drug monitoring
trigeminal neuralgia
hplc-ms/ms
карбамазепин
карбамазепин-10,11-эпоксид
терапевтический лекарственный мониторинг
невралгия тройничного нерва
вэжх-мс/мс
Online Access:https://www.vedomostincesmp.ru/jour/article/view/60

Internet

https://www.vedomostincesmp.ru/jour/article/view/60

Similar Items