Deep sequencing reveals the spectrum of BCR-ABL1 mutations upon front-line therapy resistance in chronic myeloid leukemia: An Eastern-Indian cohort study

Deep sequencing reveals the spectrum of BCR-ABL1 mutations upon front-line therapy resistance in chronic myeloid leukemia: An Eastern-Indian cohort study

The course of clinical management in chronic myeloid leukemia (CML) often faces a road-block in the form of front-line (imatinib) therapy resistance. Subsequently, several hotspot mutations were clinically validated in the kinase domain (KD) of BCR-ABL1, in deterring imatinib sensitivity and further...

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Bibliographic Details
Main Authors: Samya Dey, Soumi Basu, Shahena Shah, Debmalya Bhattacharyya, Partha Pratim Gupta, Mahasweta Acharjee, Susanta Roychoudhury, Somsubhra Nath
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cancer Treatment and Research Communications
Subjects:
Chronic myeloid leukemia (CML)
BCR-ABL1
Imatinib resistance
Kinase domain (KD) mutation
Next generation sequencing (NGS)
Online Access:http://www.sciencedirect.com/science/article/pii/S2468294222001265

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