In Vitro Characterization of Cisplatin and Pemetrexed Effects in Malignant Pleural Mesothelioma 3D Culture Phenotypes

In Vitro Characterization of Cisplatin and Pemetrexed Effects in Malignant Pleural Mesothelioma 3D Culture Phenotypes

Malignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis. The main treatment for MPM is doublet chemotherapy with Cisplatin and Pemetrexed, while ongoing trials test the efficacy of pemetrexed monotherapy. However, there is lack of evidence regarding the effects of Cisplatin...

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Bibliographic Details
Main Authors: Eleftherios D. Papazoglou, Rajesh M. Jagirdar, Olympia A. Kouliou, Eleanna Pitaraki, Chrissi Hatzoglou, Konstantinos I. Gourgoulianis, Sotirios G. Zarogiannis
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
3d cultures
cisplatin
homologous cell derived extracellular matrix
malignant pleural mesothelioma
mesothelial cells
pemetrexed
pleura
tumor spheroid
Online Access:https://www.mdpi.com/2072-6694/11/10/1446

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