Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways
Parvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. However, the roles of PV+ interneurons in the regulation of SPNs in the ventral striatum and emotional states are largely unknown. Here, we investigated whether stimula...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-05-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00110/full |
| _version_ | 1818510911564939264 |
|---|---|
| author | Xi Chen Zhiyuan Liu Chaonan Ma Lan Ma Xing Liu |
| author_facet | Xi Chen Zhiyuan Liu Chaonan Ma Lan Ma Xing Liu |
| author_sort | Xi Chen |
| collection | DOAJ |
| description | Parvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. However, the roles of PV+ interneurons in the regulation of SPNs in the ventral striatum and emotional states are largely unknown. Here, we investigated whether stimulation of ventral striatal (accumbal) PV+ interneurons would drive emotional valence in mice. We found that during conditioned place preference (CPP) training, activation of accumbal PV+ interneurons evoked place preference while suppressing them resulted in conditioned place aversion (CPA). Activation of PV+ interneurons during place conditioning increased Fos expression in SPNs in the direct pathway (dSPNs) and impaired lithium chloride-induced CPA. Activation of dSPNs and SPNs in the indirect pathway (iSPNs) induced CPP and CPA, respectively; conversely, suppression of dSPNs or iSPNs induced CPA or CPP. In addition, activation or suppression of calretinin-expressing (CR) GABAergic interneurons did not induce place preference or aversion. These data suggest that PV+ interneurons can bidirectionally determine the emotional valence through their regulation of accumbal SPN activities and raise the possibility that manipulation of PV+ interneuron activity may have the potential to alter emotional valence and treat related mental disorders. |
| first_indexed | 2024-12-10T23:26:31Z |
| format | Article |
| id | doaj.art-a57d270dc2c14912949ee461a97e5cbd |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-10T23:26:31Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-a57d270dc2c14912949ee461a97e5cbd2022-12-22T01:29:35ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-05-011310.3389/fnbeh.2019.00110455056Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output PathwaysXi ChenZhiyuan LiuChaonan MaLan MaXing LiuParvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. However, the roles of PV+ interneurons in the regulation of SPNs in the ventral striatum and emotional states are largely unknown. Here, we investigated whether stimulation of ventral striatal (accumbal) PV+ interneurons would drive emotional valence in mice. We found that during conditioned place preference (CPP) training, activation of accumbal PV+ interneurons evoked place preference while suppressing them resulted in conditioned place aversion (CPA). Activation of PV+ interneurons during place conditioning increased Fos expression in SPNs in the direct pathway (dSPNs) and impaired lithium chloride-induced CPA. Activation of dSPNs and SPNs in the indirect pathway (iSPNs) induced CPP and CPA, respectively; conversely, suppression of dSPNs or iSPNs induced CPA or CPP. In addition, activation or suppression of calretinin-expressing (CR) GABAergic interneurons did not induce place preference or aversion. These data suggest that PV+ interneurons can bidirectionally determine the emotional valence through their regulation of accumbal SPN activities and raise the possibility that manipulation of PV+ interneuron activity may have the potential to alter emotional valence and treat related mental disorders.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00110/fullparvalbumin interneuronsnucleus accumbenscalretinin interneuronsconditioned place preferenceconditioned place aversion |
| spellingShingle | Xi Chen Zhiyuan Liu Chaonan Ma Lan Ma Xing Liu Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways Frontiers in Behavioral Neuroscience parvalbumin interneurons nucleus accumbens calretinin interneurons conditioned place preference conditioned place aversion |
| title | Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways |
| title_full | Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways |
| title_fullStr | Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways |
| title_full_unstemmed | Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways |
| title_short | Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways |
| title_sort | parvalbumin interneurons determine emotional valence through modulating accumbal output pathways |
| topic | parvalbumin interneurons nucleus accumbens calretinin interneurons conditioned place preference conditioned place aversion |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00110/full |
| work_keys_str_mv | AT xichen parvalbumininterneuronsdetermineemotionalvalencethroughmodulatingaccumbaloutputpathways AT zhiyuanliu parvalbumininterneuronsdetermineemotionalvalencethroughmodulatingaccumbaloutputpathways AT chaonanma parvalbumininterneuronsdetermineemotionalvalencethroughmodulatingaccumbaloutputpathways AT lanma parvalbumininterneuronsdetermineemotionalvalencethroughmodulatingaccumbaloutputpathways AT xingliu parvalbumininterneuronsdetermineemotionalvalencethroughmodulatingaccumbaloutputpathways |