Glycogen synthase kinase 3 inhibition enhances mineral nodule formation by cementoblasts in vitro

Glycogen synthase kinase 3 inhibition enhances mineral nodule formation by cementoblasts in vitro

Abstract This study aimed to investigate whether GSK-3 inhibition (CHIR99021) effectively promoted mineralization by cementoblasts (OCCM-30). OCCM-30 cells were used and treated with different concentrations of CHIR99021 (2.5, 5, and 10 mM). Experiments included proliferation and viability, cellular...

Full description

Bibliographic Details
Main Authors:	Henrique ABDALLA, Rafael STORINO, Amanda BANDEIRA, Lucas TEIXEIRA, Ana MILLÁS, Paulo LISBOA-FILHO, Kamila KANTOVITZ, Francisco NOCITI JUNIOR
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Pesquisa Odontológica 2023-11-01
Series:	Brazilian Oral Research
Subjects:	Wnt Signaling Pathway Glycogen Synthase Kinase 3 Dental Cementum
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242023000100294&tlng=en

Similar Items

Glycogen synthase kinase 3 (GSK-3) and its inhibitors : drug discovery and development /
by: Martinez, Ana, 1961-, et al.
Published: (2006)

Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
by: Cheenpracha, Sarot, et al.
Published: (2009)

Glycogen Synthase Kinase 3β in Cancer Biology and Treatment
by: Takahiro Domoto, et al.
Published: (2020-06-01)

Regulation of Phosphorylation of Glycogen Synthase Kinase 3α and the Correlation with Sperm Motility in Human
by: Seung Hyun Park, et al.
Published: (2024-04-01)

Synthesis and Evaluation of 5-(Heteroarylmethylene)hydantoins as Glycogen Synthase Kinase-3β Inhibitors
by: Nicholas O. Schneider, et al.
Published: (2024-04-01)

On the role of glycogen synthase kinases in the molecular mechanisms of stress conditions and prospects for the use of lithium ascorbate
by: I. Yu. Torshin, et al.
Published: (2022-10-01)

Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
by: Wang Man, et al.
Published: (2024-11-01)

Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
by: E. C. de Heer, et al.
Published: (2023-06-01)

Effect of Xenon on the Phosphorylation of Glycogen Synthase Kinase 3β and Antioxidant Enzymes in Rat Brain
by: A. N. Kuzovlev, et al.
Published: (2021-01-01)

Akt signaling pathway: a potential therapy for Alzheimer’s disease through glycogen synthase kinase 3 beta inhibition
by: Joshua Limantoro, et al.
Published: (2023-11-01)

Glycogen synthase activity in Candida albicans is partly controlled by the functional ortholog of Saccharomyces cerevisiae Gac1p
by: Jian Miao, et al.
Published: (2024-10-01)

Interleukin 24 Promotes Mitochondrial Dysfunction, Glucose Regulation, and Apoptosis by Inactivating Glycogen Synthase Kinase 3 Beta in Human Prostate Cancer Cells
by: Anastassiya Kim, et al.
Published: (2025-02-01)

In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [<sup>11</sup>C]OCM-44 and [<sup>18</sup>F]OCM-50 in Non-Human Primates
by: Kelly Smart, et al.
Published: (2023-01-01)

Glycogen Metabolism and Its Role in Growth and Encystation in <i>Entamoeba histolytica</i>
by: Jordan Wesel, et al.
Published: (2023-07-01)

Glycogen storage disease type 0 due to a novel frameshift mutation in glycogen synthase 2 (GYS2) gene in a child presenting with fasting hypoglycemia and postprandial hyperglycemia
by: Bülent Hacıhamdioğlu, et al.
Published: (2018-10-01)

Glycophagy is involved in cardiac glycogen regulation in response to exercise
by: Samuel L. James, et al.
Published: (2024-01-01)

Testicular Glycogen Metabolism: An Overlooked Source of Energy for Spermatogenesis?
by: Ricardo Silva, et al.
Published: (2022-09-01)

Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma
by: Andrew Hsu, et al.
Published: (2022-12-01)

Glycogen synthase kinase 3 activity enhances liver inflammation in MASH
by: Mireille Khoury, et al.
Published: (2024-06-01)

Postprandial Glycogen Content Is Increased in the Hepatocytes of Human and Rat Cirrhotic Liver
by: Natalia N. Bezborodkina, et al.
Published: (2021-04-01)

Effects of GSK-3 inhibition on LPS-induced neuroinflammation and IL-10 production in microglia
by: Md Zain, Zuhaida
Published: (2016)

Association of glycogen synthase kinase-3β with cognitive impairment in type 2 diabetes patients: a six-year follow-up study
by: Wei Wei, et al.
Published: (2024-04-01)

The Effect of Xenon on the Activity of Glycogen Synthase Kinase-Зβ in the Perifocal Zone of Ischemic Cerebral Infarction (Experimental Study)
by: A. V. Ershov, et al.
Published: (2023-04-01)

Glycogen Synthase Kinase-3β Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4<sup>+</sup> T Lymphocytes
by: Cheng-Chieh Tsai, et al.
Published: (2020-06-01)

Glucocorticoid Receptor Mediates Cortisol Regulation of Glycogen Metabolism in Gills of the Euryhaline Tilapia (<i>Oreochromis mossambicus</i>)
by: Chien-Yu Wu, et al.
Published: (2023-05-01)

AR-A014418, a glycogen synthase kinase-3β inhibitor, mitigates lipopolysaccharide-induced inflammation in rat dental pulp stem cells via NLR family pyrin domain containing 3 inflammasome impairment
by: Huilan Xie, et al.
Published: (2023-10-01)

Involvement of Glycogen Synthase Kinase 3β (GSK3β) in Formation of Phosphorylated Tau and Death of Retinal Ganglion Cells of Rats Caused by Optic Nerve Crush
by: Yurie Fukiyama, et al.
Published: (2023-08-01)

In silico evaluation of cis-dihydroxy-indeno[1,2-d]imidazolones as inhibitors of glycogen synthase kinase-3: synthesis, molecular docking, physicochemical data, ADMET,MD simulation, and DFT calculations
by: Nahid Mahmoodi, et al.
Published: (2024-07-01)

A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells
by: Nigel Kurgan, et al.
Published: (2019-10-01)

Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in Drosophila
by: Akanksha Onkar, et al.
Published: (2023-10-01)

Biochemical investigations in glycogen storage disease
by: P Ozand, et al.
Published: (1963-10-01)

When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex
by: Chenchen Li, et al.
Published: (2023-09-01)

New Solutions in Single-Cell Protein Production from Methane: Construction of Glycogen-Deficient Mutants of <i>Methylococcus capsulatus</i> MIR
by: Sergey Y. But, et al.
Published: (2024-05-01)

Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity
by: Ikko Sakamoto, et al.
Published: (2024-11-01)

Cementum attachment protein‐derived peptide induces cementum formation
by: Lía Hoz Rodríguez, et al.
Published: (2025-02-01)

Glycogen storage disorder types IX: the mutation spectrum and ethnic distribution
by: Bita Geramizadeh, et al.
Published: (2024-12-01)

An optimized method for tissue glycogen quantification
by: Kyle J. Schaubroeck, et al.
Published: (2022-02-01)

Odontogenic differentiation of dental pulp stem cells by glycogen synthase kinase-3β inhibitory peptides
by: Vidhyashree Rajasekar, et al.
Published: (2025-02-01)

Role of glycogen metabolism in Clostridioides difficile virulence
by: Md Kamrul Hasan, et al.
Published: (2024-09-01)

Transcriptome Analysis Reveals Mycelial and Fruiting Responses to Lithium Chloride in <i>Coprinopsis cinerea</i>
by: Po-Lam Chan, et al.
Published: (2024-02-01)