A Rare SPRY4 Gene Mutation Is Associated With Anosmia and Adult-Onset Isolated Hypogonadotropic Hypogonadism

A Rare SPRY4 Gene Mutation Is Associated With Anosmia and Adult-Onset Isolated Hypogonadotropic Hypogonadism

Background: Isolated hypogonadotropic hypogonadism (IHH) is a rare, clinically heterogeneous condition, caused by the deficient secretion or action of gonadotropin releasing hormone (GnRH). It can manifest with absent or incomplete sexual maturation, or as infertility at adult-age; in a half of case...

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Podrobná bibliografie
Hlavní autoři: Rita Indirli, Biagio Cangiano, Eriselda Profka, Giovanna Mantovani, Luca Persani, Maura Arosio, Marco Bonomi, Emanuele Ferrante
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2019-11-01
Edice:Frontiers in Endocrinology
Témata:
Kallmann syndrome
anosmia
isolated hypogonadotropic hypogonadism
central hypogonadism
SPRY4
On-line přístup:https://www.frontiersin.org/article/10.3389/fendo.2019.00781/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00781/full

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