PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS
The aim of the study is to determine the prevalence of plasmid-mediated resistance genes among uro- pathogens from hospitalized patients with chronic pyelonephritis. Methods. A cross-sectional study of 105patients with chronic pyelonephritis and different stage of chronic kidney disease, was car...
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| Format: | Article |
| Language: | English |
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State Institution «Institute of Nephrology NAMS of Ukraine"
2016-06-01
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| Series: | Український Журнал Нефрології та Діалізу |
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| Online Access: | https://ukrjnd.com.ua/index.php/journal/article/view/194 |
| _version_ | 1797261456996040704 |
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| author | О. Chub O. Bilchenko |
| author_facet | О. Chub O. Bilchenko |
| author_sort | О. Chub |
| collection | DOAJ |
| description |
The aim of the study is to determine the prevalence of plasmid-mediated resistance genes among uro- pathogens from hospitalized patients with chronic pyelonephritis.
Methods. A cross-sectional study of 105patients with chronic pyelonephritis and different stage of chronic kidney disease, was carried. Screening for the presence ofplasmid-mediated genes was performed by polymerase chain reaction. Determining the risk factors was performed by analysis of prevalence Odd-ratio.
Results. The prevalence of plasmid-mediated resistance mechanisms among uropathogens is 36.7%, mainly due to extended-spectrum p-lactamase (25%). The main factors related with appearance of plasmid-mediated resistance genes were age range above 55 years (OR 3.05), hypertension (OR 2.57), Chronic Kidney Disease stage ІІІ (OR 2,03) and V (OR 1,1), in-patient treatment history (OR 2.02), duration of CP more than 10 years (OR 1,97), history of using antibiotics last year (OR 1,41).
Conclusion. Isolation and detection of plasmid-mediated resistance mechanisms among urinary strains are essential for the selection of the most effective antibiotic for the empiric treatment.
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| first_indexed | 2024-04-24T23:41:31Z |
| format | Article |
| id | doaj.art-a57d5d323e964645b7a4b9bb74d6f496 |
| institution | Directory Open Access Journal |
| issn | 2304-0238 2616-7352 |
| language | English |
| last_indexed | 2024-04-24T23:41:31Z |
| publishDate | 2016-06-01 |
| publisher | State Institution «Institute of Nephrology NAMS of Ukraine" |
| record_format | Article |
| series | Український Журнал Нефрології та Діалізу |
| spelling | doaj.art-a57d5d323e964645b7a4b9bb74d6f4962024-03-15T12:23:09ZengState Institution «Institute of Nephrology NAMS of Ukraine"Український Журнал Нефрології та Діалізу2304-02382616-73522016-06-012(50)10.31450/ukrjnd.2(50).2016.04194PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORSО. Chub0O. Bilchenko1Kharkiv Medical Academy of Postgraduate EducationKharkiv Medical Academy of Postgraduate Education The aim of the study is to determine the prevalence of plasmid-mediated resistance genes among uro- pathogens from hospitalized patients with chronic pyelonephritis. Methods. A cross-sectional study of 105patients with chronic pyelonephritis and different stage of chronic kidney disease, was carried. Screening for the presence ofplasmid-mediated genes was performed by polymerase chain reaction. Determining the risk factors was performed by analysis of prevalence Odd-ratio. Results. The prevalence of plasmid-mediated resistance mechanisms among uropathogens is 36.7%, mainly due to extended-spectrum p-lactamase (25%). The main factors related with appearance of plasmid-mediated resistance genes were age range above 55 years (OR 3.05), hypertension (OR 2.57), Chronic Kidney Disease stage ІІІ (OR 2,03) and V (OR 1,1), in-patient treatment history (OR 2.02), duration of CP more than 10 years (OR 1,97), history of using antibiotics last year (OR 1,41). Conclusion. Isolation and detection of plasmid-mediated resistance mechanisms among urinary strains are essential for the selection of the most effective antibiotic for the empiric treatment. https://ukrjnd.com.ua/index.php/journal/article/view/194chronic pyelonephritis, antibiotics, resistance, risk factors, plasmids. |
| spellingShingle | О. Chub O. Bilchenko PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS Український Журнал Нефрології та Діалізу chronic pyelonephritis, antibiotics, resistance, risk factors, plasmids. |
| title | PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS |
| title_full | PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS |
| title_fullStr | PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS |
| title_full_unstemmed | PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS |
| title_short | PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS |
| title_sort | plasmid induced antibiotic resistance among pathogens of chronic pyelonephritis prevalence of genes and major risk factors |
| topic | chronic pyelonephritis, antibiotics, resistance, risk factors, plasmids. |
| url | https://ukrjnd.com.ua/index.php/journal/article/view/194 |
| work_keys_str_mv | AT ochub plasmidinducedantibioticresistanceamongpathogensofchronicpyelonephritisprevalenceofgenesandmajorriskfactors AT obilchenko plasmidinducedantibioticresistanceamongpathogensofchronicpyelonephritisprevalenceofgenesandmajorriskfactors |