Bacterial Subversion of Autophagy in Cystic Fibrosis
Cystic fibrosis (CF) is a genetic disease affecting more than 70,000 people worldwide. It is caused by a mutation in the cftr gene, a chloride ion transporter localized in the plasma membrane of lung epithelial cells and other organs. The loss of CFTR function alters chloride, bicarbonate, and water...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.760922/full |
| _version_ | 1818602500352114688 |
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| author | Verónica Roxana Flores-Vega Verónica Roxana Flores-Vega Silvia Yalid Vargas-Roldán Silvia Yalid Vargas-Roldán José Luis Lezana-Fernández José Luis Lezana-Fernández Ricardo Lascurain José Ignacio Santos-Preciado Roberto Rosales-Reyes |
| author_facet | Verónica Roxana Flores-Vega Verónica Roxana Flores-Vega Silvia Yalid Vargas-Roldán Silvia Yalid Vargas-Roldán José Luis Lezana-Fernández José Luis Lezana-Fernández Ricardo Lascurain José Ignacio Santos-Preciado Roberto Rosales-Reyes |
| author_sort | Verónica Roxana Flores-Vega |
| collection | DOAJ |
| description | Cystic fibrosis (CF) is a genetic disease affecting more than 70,000 people worldwide. It is caused by a mutation in the cftr gene, a chloride ion transporter localized in the plasma membrane of lung epithelial cells and other organs. The loss of CFTR function alters chloride, bicarbonate, and water transport through the plasma membrane, promoting the production of a thick and sticky mucus in which bacteria including Pseudomonas aeruginosa and Burkholderia cenocepacia can produce chronic infections that eventually decrease the lung function and increase the risk of mortality. Autophagy is a well-conserved lysosomal degradation pathway that mediates pathogen clearance and plays an important role in the control of bacterial infections. In this mini-review, we describe the principal strategies used by P. aeruginosa and B. cenocepacia to survive and avoid microbicidal mechanisms within the autophagic pathway leading to the establishment of chronic inflammatory immune responses that gradually compromise the lung function and the life of CF patients. |
| first_indexed | 2024-12-16T13:08:16Z |
| format | Article |
| id | doaj.art-a57d92ca7f4e49bea968134dfc95f8b4 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-16T13:08:16Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-a57d92ca7f4e49bea968134dfc95f8b42022-12-21T22:30:42ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-10-011110.3389/fcimb.2021.760922760922Bacterial Subversion of Autophagy in Cystic FibrosisVerónica Roxana Flores-Vega0Verónica Roxana Flores-Vega1Silvia Yalid Vargas-Roldán2Silvia Yalid Vargas-Roldán3José Luis Lezana-Fernández4José Luis Lezana-Fernández5Ricardo Lascurain6José Ignacio Santos-Preciado7Roberto Rosales-Reyes8Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoEscuela de Ciencias de la Salud, Universidad del Valle de México, Campus Coyoacán, Mexico City, MexicoUnidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Mexico City, MexicoLaboratorio de Fisiología Respiratoria y la Clínica de Fibrosis Quística, Hospital Infantil de México Federico Gómez, Mexico City, MexicoDirección Médica, Asociación Mexicana de Fibrosis Quística, Mexico City, MexicoDepartamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoUnidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoUnidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoCystic fibrosis (CF) is a genetic disease affecting more than 70,000 people worldwide. It is caused by a mutation in the cftr gene, a chloride ion transporter localized in the plasma membrane of lung epithelial cells and other organs. The loss of CFTR function alters chloride, bicarbonate, and water transport through the plasma membrane, promoting the production of a thick and sticky mucus in which bacteria including Pseudomonas aeruginosa and Burkholderia cenocepacia can produce chronic infections that eventually decrease the lung function and increase the risk of mortality. Autophagy is a well-conserved lysosomal degradation pathway that mediates pathogen clearance and plays an important role in the control of bacterial infections. In this mini-review, we describe the principal strategies used by P. aeruginosa and B. cenocepacia to survive and avoid microbicidal mechanisms within the autophagic pathway leading to the establishment of chronic inflammatory immune responses that gradually compromise the lung function and the life of CF patients.https://www.frontiersin.org/articles/10.3389/fcimb.2021.760922/fullcystic fibrosisautophagysubversionBurkholderia cenocepaciaPseudomonas aeruginosa |
| spellingShingle | Verónica Roxana Flores-Vega Verónica Roxana Flores-Vega Silvia Yalid Vargas-Roldán Silvia Yalid Vargas-Roldán José Luis Lezana-Fernández José Luis Lezana-Fernández Ricardo Lascurain José Ignacio Santos-Preciado Roberto Rosales-Reyes Bacterial Subversion of Autophagy in Cystic Fibrosis Frontiers in Cellular and Infection Microbiology cystic fibrosis autophagy subversion Burkholderia cenocepacia Pseudomonas aeruginosa |
| title | Bacterial Subversion of Autophagy in Cystic Fibrosis |
| title_full | Bacterial Subversion of Autophagy in Cystic Fibrosis |
| title_fullStr | Bacterial Subversion of Autophagy in Cystic Fibrosis |
| title_full_unstemmed | Bacterial Subversion of Autophagy in Cystic Fibrosis |
| title_short | Bacterial Subversion of Autophagy in Cystic Fibrosis |
| title_sort | bacterial subversion of autophagy in cystic fibrosis |
| topic | cystic fibrosis autophagy subversion Burkholderia cenocepacia Pseudomonas aeruginosa |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.760922/full |
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