Loss of dysbindin-1, a risk gene for schizophrenia, leads to impaired group 1 metabotropic glutamate receptor function in mice.

Loss of dysbindin-1, a risk gene for schizophrenia, leads to impaired group 1 metabotropic glutamate receptor function in mice.

The expression of dysbindin-1, a protein coded by the risk gene dtnbp1, is reduced in the brains of schizophrenia patients. Evidence indicates a role of dysbindin-1 in dopaminergic and glutamatergic transmission. Glutamatergic transmission and plasticity at excitatory synapses is critically regulat...

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Bibliographic Details
Main Authors: Sanjeev K Bhardwaj, Richard eRyan, Tak Pan Wong, Lalit K. Srivastava
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Cognition
Hippocampus
Memory
Schizophrenia
animal model
synaptic plasticity.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00072/full

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