The methyl ester of rosuvastatin elicited an endothelium-independent and 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent relaxant effect in rat aorta

The methyl ester of rosuvastatin elicited an endothelium-independent and 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent relaxant effect in rat aorta

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The relaxant effect of the methyl ester of rosuvastatin was evaluated on aortic rings from male Wistar rats (250-300 g, 6 rats for each experimental group) with and without endothelium precontracted with 1.0 µM phenylephrine. The methyl ester presented a slightly greater potency than rosuvastatin in...

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Bibliographic Details
Main Authors: J.S. López-Canales, P. López-Sanchez, V.M. Perez-Alvarez, I. Wens-Flores, A.C. Polanco, E. Castillo-Henkel, C. Castillo-Henkel
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Rat aorta
Rosuvastatin methyl ester
Endothelium-independent relaxation
Potassium channels
NOS-2
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000500009

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