Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases
Since neurons have long neurites including axons, it is crucial for the axons to transport many intracellular substances such as proteins and mitochondria in order to maintain their morphology and function. In addition, mRNAs have also been shown to be transported within axons. RNA-binding proteins...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2021.697973/full |
| _version_ | 1818872101388419072 |
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| author | Seiichi Nagano Seiichi Nagano Toshiyuki Araki |
| author_facet | Seiichi Nagano Seiichi Nagano Toshiyuki Araki |
| author_sort | Seiichi Nagano |
| collection | DOAJ |
| description | Since neurons have long neurites including axons, it is crucial for the axons to transport many intracellular substances such as proteins and mitochondria in order to maintain their morphology and function. In addition, mRNAs have also been shown to be transported within axons. RNA-binding proteins form complexes with mRNAs, and regulate transport of the mRNAs to axons, as well as locally translate them into proteins. Local translation of mRNAs actively occurs during the development and damage of neurons, and plays an important role in axon elongation, regeneration, and synapse formation. In recent years, it has been reported that impaired axonal transport and local translation of mRNAs may be involved in the pathogenesis of some neurodegenerative diseases. In this review, we discuss the significance of mRNA axonal transport and their local translation in amyotrophic lateral sclerosis/frontotemporal dementia, spinal muscular atrophy, Alzheimer’s disease, and fragile X syndrome. |
| first_indexed | 2024-12-19T12:33:27Z |
| format | Article |
| id | doaj.art-a57ff7fed55441b6bebb2b779deb61c2 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-19T12:33:27Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-a57ff7fed55441b6bebb2b779deb61c22022-12-21T20:21:13ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992021-06-011410.3389/fnmol.2021.697973697973Axonal Transport and Local Translation of mRNA in Neurodegenerative DiseasesSeiichi Nagano0Seiichi Nagano1Toshiyuki Araki2Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, JapanSince neurons have long neurites including axons, it is crucial for the axons to transport many intracellular substances such as proteins and mitochondria in order to maintain their morphology and function. In addition, mRNAs have also been shown to be transported within axons. RNA-binding proteins form complexes with mRNAs, and regulate transport of the mRNAs to axons, as well as locally translate them into proteins. Local translation of mRNAs actively occurs during the development and damage of neurons, and plays an important role in axon elongation, regeneration, and synapse formation. In recent years, it has been reported that impaired axonal transport and local translation of mRNAs may be involved in the pathogenesis of some neurodegenerative diseases. In this review, we discuss the significance of mRNA axonal transport and their local translation in amyotrophic lateral sclerosis/frontotemporal dementia, spinal muscular atrophy, Alzheimer’s disease, and fragile X syndrome.https://www.frontiersin.org/articles/10.3389/fnmol.2021.697973/fullaxonal transportlocal translationmRNAamyotrophic lateral sclerosisfrontotemporal dementiaspinal muscular atrophy |
| spellingShingle | Seiichi Nagano Seiichi Nagano Toshiyuki Araki Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases Frontiers in Molecular Neuroscience axonal transport local translation mRNA amyotrophic lateral sclerosis frontotemporal dementia spinal muscular atrophy |
| title | Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases |
| title_full | Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases |
| title_fullStr | Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases |
| title_full_unstemmed | Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases |
| title_short | Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases |
| title_sort | axonal transport and local translation of mrna in neurodegenerative diseases |
| topic | axonal transport local translation mRNA amyotrophic lateral sclerosis frontotemporal dementia spinal muscular atrophy |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2021.697973/full |
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